0000000000418242

AUTHOR

Stephan Lautenschlager

0000-0003-3472-814x

showing 3 related works from this author

Open data and digital morphology

2017

International audience; Over the past two decades, the development of methods for visualizing and analysing specimens digitally, in three and even four dimensions, has transformed the study of living and fossil organisms. However, the initial promise that the widespread application of such methods would facilitate access to the underlying digital data has not been fully achieved. The underlying datasets for many published studies are not readily or freely available, introducing a barrier to verification and reproducibility, and the reuse of data. There is no current agreement or policy on the amount and type of data that should be made available alongside studies that use, and in some cases…

0106 biological sciences0301 basic medicineLife Sciences & Biomedicine - Other TopicsDYNAMICSComputer scienceDatasets as TopicReuse01 natural sciencesFOSSILSthree-dimensional modelsNaturvetenskapData CurationGeneral Environmental ScienceEcologypalaeontology[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]70General Medicine11 Medical And Health SciencesCCbiomechanics Keywords: digital dataOpen dataPerspectiveComputer data storage[SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/PaleontologyGeneral Agricultural and Biological SciencesNatural SciencesLife Sciences & BiomedicineDatasets as Topic1001TISSUESphenotypeBest practiceDigital dataLibrary science25Environmental Sciences & Ecology010603 evolutionary biologyBiological Science DisciplinesGeneral Biochemistry Genetics and Molecular BiologyQA76functional analysisSet (abstract data type)03 medical and health sciencesPALEONTOLOGYBiologySubject Category: Morphology and biomechanics Subject Areas: evolutionvisualizationdigital dataEvolutionary BiologyScience & TechnologyTOMOGRAPHIC MICROSCOPYMorphology and BiomechanicsGeneral Immunology and Microbiologybusiness.industryResearchQHReproducibility of Resultscomputed tomographyPERFORMANCE06 Biological Sciences144Data scienceEVOLUTIONVisualization030104 developmental biologyVISUALIZATION07 Agricultural And Veterinary SciencesbusinessProceedings of the Royal Society B: Biological Sciences
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Molecular characterization of Treponema pallidum subsp. pallidum in Switzerland and France with a new multilocus sequence typing scheme

2018

Syphilis is an important public health problem and an increasing incidence has been noted in recent years. Characterization of strain diversity through molecular data plays a critical role in the epidemiological understanding of this re-emergence. We here propose a new high-resolution multilocus sequence typing (MLST) scheme for Treponema pallidum subsp. pallidum (TPA). We analyzed 30 complete and draft TPA genomes obtained directly from clinical samples or from rabbit propagated strains to identify suitable typing loci and tested the new scheme on 120 clinical samples collected in Switzerland and France. Our analyses yielded three loci with high discriminatory power: TP0136, TP0548, and TP…

10207 Department of AnthropologyArtificial Gene Amplification and ExtensionGene mutationPathology and Laboratory MedicineFrance/epidemiologyBiochemistryPolymerase Chain Reactionlaw.inventionSwitzerland/epidemiologylcsh:SciencePhylogenyMammalsBacterialEukaryotaGeneral MedicineMacrolides/pharmacologyMultilocus Sequence Typing/methods3. Good healthBacterial PathogensNucleic acidsMedical MicrobiologyLeporidsMacrolidesAlleles; Anti-Bacterial Agents/pharmacology; DNA Bacterial/genetics; France/epidemiology; Genome Bacterial; Genotype; Globus Pallidus; Macrolides/pharmacology; Multilocus Sequence Typing/methods; Phylogeny; Polymorphism Single Nucleotide; RNA Ribosomal 23S/genetics; Sequence Analysis DNA/methods; Switzerland/epidemiology; Syphilis/epidemiology; Treponema pallidum/geneticsGeneral Agricultural and Biological SciencesSwitzerlandGenotypeSequence analysis030106 microbiologySexually Transmitted Diseases1100 General Agricultural and Biological SciencesGlobus PallidusMicrobiologyAnti-Bacterial Agents/pharmacology10127 Institute of Evolutionary Biology and Environmental Studies03 medical and health sciences1300 General Biochemistry Genetics and Molecular Biology23S ribosomal RNAGeneticsTypingSyphilisPolymorphismNon-coding RNAMolecular Biology TechniquesMicrobial PathogensMolecular BiologyAllelesRibosomal1000 MultidisciplinaryGenitourinary Infectionslcsh:ROrganismsBiology and Life SciencesDNATropical DiseasesTreponema pallidum/genetics030104 developmental biologyGenetic LociGeneral Biochemistrylcsh:QMultilocus Sequence Typing0301 basic medicineBacterial DiseasesBacterial/geneticslcsh:MedicineTreponematosesGeographical LocationslawGenotypeMedicine and Health Sciences23S/geneticsTreponema PallidumPolymerase chain reactionGeneticsMultidisciplinaryTreponemaGenome10177 Dermatology ClinicSingle NucleotideAnimal Models10218 Institute of Legal MedicineAnti-Bacterial AgentsDNA/methodsEuropeRNA Ribosomal 23SInfectious DiseasesRibosomal RNAExperimental Organism SystemsVertebratesFranceRabbitsPathogensSequence AnalysisResearch ArticleNeglected Tropical DiseasesDNA BacterialCell biologyCellular structures and organellesUrology610 Medicine & healthGenetics and Molecular BiologyBiologyResearch and Analysis MethodsPolymorphism Single NucleotideAnimalsEuropean Unionddc:613Syphilis/epidemiologySequence Analysis DNAbiology.organism_classificationddc:616.8People and PlacesAmniotesMultilocus sequence typingRNARibosomesGenome BacterialPLoS ONE
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Table S1 from Open data and digital morphology

2017

Summary of main online repositories for 3D digital morphological data.

ComputingMethodologies_PATTERNRECOGNITIONComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONComputingMethodologies_COMPUTERGRAPHICS
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