0000000000418689

AUTHOR

Auxiliadora Aracil-fernández

showing 3 related works from this author

The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence

2017

Abstract Binge-eating is considered a specific form of overeating characterized by intermittent and high caloric food intake in a short period of time. Epidemiologic studies support a positive relation between the ingestion of fat and ethanol (EtOH), specifically among adolescent subjects. The aim of this work was to clarify the role of the compulsive, limited and intermittent intake of a high-fat food during adolescence on the rewarding effects of EtOH. After binge-eating for 2 h, three days a week from postnatal day (PND) 29, the reinforcing effects of EtOH were tested with EtOH self-administration (SA), conditioned place preference (CPP) and ethanol locomotor sensitization procedures in …

Maleendocrine systemmedicine.medical_specialtyTime FactorsSelf AdministrationNucleus accumbensDiet High-FatMice03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineRewardInternal medicinemental disordersmedicineAnimalsIngestionBulimiaOvereatingreproductive and urinary physiologyPharmacologyEthanolBinge eatingDrug Administration RoutesCentral Nervous System DepressantsConditioned place preference030227 psychiatryVentral tegmental areaDisease Models Animalmedicine.anatomical_structureEndocrinologyAnimals NewbornAnesthesiaConditioning Operantmedicine.symptomμ-opioid receptorSelf-administrationPsychologyLocomotion030217 neurology & neurosurgeryNeuropharmacology
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Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice

2016

Binge eating is a specific form of overeating characterized by intermittent excessive eating. In addition to altering the neurobiological reward system, several studies have highlighted that consumption of palatable food increases vulnerability to drug use. The aim of the present study was to evaluate the effects of a high-fat diet consumed in a binge pattern during adolescence on the reinforcing effects of cocaine. After 40 days of binge-eating for 2 h, three days a week (PND 29–69), the reinforcing effects of cocaine on conditioning place preference and intravenous self-administration paradigm were evaluated in adolescent male mice. Circulating leptin and ghrelin levels and the effects of…

0301 basic medicineLeptinMalemedicine.medical_specialtyConditioning ClassicalDrug-Seeking BehaviorReceptors Opioid muGene ExpressionSelf AdministrationNucleus accumbensAnxietyDiet High-FatAdolescentsNucleus Accumbens03 medical and health sciencesCellular and Molecular NeuroscienceMice0302 clinical medicineCocaineReceptor Cannabinoid CB1RewardInternal medicinemedicineAnimalsOvereatingBulimiaPharmacologyBinge eatingdigestive oral and skin physiologyBody WeightVentral Tegmental AreaConditioned place preferenceGhrelinCocaïnaVentral tegmental areaAlimentació030104 developmental biologyEndocrinologymedicine.anatomical_structureGhrelinBrain stimulation rewardmedicine.symptomPsychologySelf-administrationCorticosterone030217 neurology & neurosurgery
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Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine.

2013

This study was aimed to evaluate the involvement of CB2 cannabinoid receptors (CB2r) in the rewarding, reinforcing and motivational effects of nicotine. Conditioned place preference (CPP) and intravenous self-administration experiments were carried out in knockout mice lacking CB2r (CB2KO) and wild-type (WT) littermates treated with the CB2r antagonist AM630 (1 and 3 mg/kg). Gene expression analyses of tyrosine hydroxylase (TH) and α3- and α4-nicotinic acetylcholine receptor subunits (nAChRs) in the ventral tegmental area (VTA) and immunohistochemical studies to elucidate whether CB2r colocalized with α3- and α4-nAChRs in the nucleus accumbens and VTA were performed. Mecamylamine-precipitat…

MaleNicotinemedicine.medical_treatmentNicotinaRecompensa (Psicologia)Self AdministrationPharmacologyNucleus accumbensNucleus AccumbensNicotineReceptor Cannabinoid CB2MiceRewardCannabinoides -- ReceptorsmedicineAnimalsAcetylcholine receptorPharmacologyMice KnockoutTyrosine hydroxylaseVentral Tegmental Areamedicine.diseaseConditioned place preferenceSubstance Withdrawal SyndromeVentral tegmental areaPsychiatry and Mental healthmedicine.anatomical_structureNicotine withdrawalConditioning OperantOriginal ArticleCannabinoidPsychologyReinforcement Psychologymedicine.drugNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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