The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence

6533b7ddfe1ef96bd1275379

RESEARCH PRODUCT

The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence

Juan Carlos Ledesma María A. Aguilar Sandra Montagud-romero Auxiliadora Aracil-fernández José Miñarro M. Carmen Blanco-gandía Marta Rodríguez-arias Francisco Navarrete Jorge Manzanares

subject

Male endocrine system medicine.medical_specialty Time Factors Self Administration Nucleus accumbens Diet High-Fat Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Reward Internal medicine mental disorders medicine Animals Ingestion Bulimia Overeating reproductive and urinary physiology Pharmacology Ethanol Binge eating Drug Administration Routes Central Nervous System Depressants Conditioned place preference 030227 psychiatry Ventral tegmental area Disease Models Animal medicine.anatomical_structure Endocrinology Animals Newborn Anesthesia Conditioning Operant medicine.symptom μ-opioid receptor Self-administration Psychology Locomotion 030217 neurology & neurosurgery

description

Abstract Binge-eating is considered a specific form of overeating characterized by intermittent and high caloric food intake in a short period of time. Epidemiologic studies support a positive relation between the ingestion of fat and ethanol (EtOH), specifically among adolescent subjects. The aim of this work was to clarify the role of the compulsive, limited and intermittent intake of a high-fat food during adolescence on the rewarding effects of EtOH. After binge-eating for 2 h, three days a week from postnatal day (PND) 29, the reinforcing effects of EtOH were tested with EtOH self-administration (SA), conditioned place preference (CPP) and ethanol locomotor sensitization procedures in young adult mice. Animals in the high fat binge (HFB) group that underwent the EtOH SA procedure presented greater EtOH consumption and a higher motivation to obtain the drug. HFB mice also developed preference for the paired compartment in the CPP with a subthreshold dose of EtOH. Independently of the diet, mice developed EtOH-induced locomotor sensitization. After the SA procedure, HFB mice exhibited reduced levels of the mu opioid receptor (MOr) and increased cannabinoid 1 receptor (CB1r) gene expression in the nucleus accumbens (N Acc), and decreased of tyrosine hydroxylase (TH) gene expression in the ventral tegmental area (VTA). Taken together the results suggest that bingeing on fat may represent a vulnerability factor to an escalation of EtOH consumption.

year	journal	country	edition	language
2017-01-03	Neuropharmacology

https://doi.org/10.1016/j.neuropharm.2017.04.040