0000000000419171

AUTHOR

Alexandra Marx

showing 2 related works from this author

A 35-year effective treatment of catecholaminergic polymorphic ventricular tachycardia with propafenone

2018

Key Teaching Points • Despite proven catecholaminergic polymorphic ventricular tachycardia (CPVT) with pathogen RyR2 mutation and recurrent syncope, patients could have a favorable long-term outcome over 35 years under treatment. • Propafenone could be effective for treatment of patients with CPVT. • The beneficial effect of the monotherapy with propafenone in our patient may result from the combined antiarrhythmic effect of this drug with Na+ channel blockade and beta blocker capabilities.

medicine.medical_specialtyPolymorphic premature ventricular beatsmedicine.drug_classCase ReportPropafenone030204 cardiovascular system & hematologyCatecholaminergic polymorphic ventricular tachycardiaRyanodine receptor 203 medical and health sciences0302 clinical medicinePropafenoneInternal medicineMedicineEffective treatment030212 general & internal medicineExercise-induced syncopeBeta blockerbusiness.industrymedicine.diseaseBlockadeExercise-induced syncopeCatecholaminergic polymorphic ventricular tachycardiacardiovascular systemCardiologyAntiarrhythmic effectCardiology and Cardiovascular MedicinebusinessRyanodine receptor mutationmedicine.drugHeartRhythm Case Reports
researchProduct

Identification of major histocompatibility complex class II-associated peptides derived from freshly prepared rat Langerhans cells using MALDI-PSD an…

2000

The isolation and identification is described of MHC class II-bound peptides derived from Langerhans cells. A combination of preparative micro-HPLC, MALDI-MS, Edman degradation was used for determining the amino acid sequence of MHC-associated peptides. Sample handling was crucial because fractions containing trace amounts of material require immediate storage at −80 °C to prevent peptide losses.

Langerhans cellPeptideMass spectrometryBiochemistryMass SpectrometryAnalytical ChemistryMHC class IElectrochemistrymedicineAnimalsEnvironmental ChemistryPeptide sequenceSpectroscopySkinchemistry.chemical_classificationSample handlingChromatographyMajor Histocompatibility Complex Class IIbiologyEdman degradationHistocompatibility Antigens Class IIRatsmedicine.anatomical_structurechemistryBiochemistryRats Inbred LewLangerhans Cellsbiology.protein
researchProduct