0000000000423052
AUTHOR
Jesús Gil
Postoperative Costs Associated With Outcomes After Cardiac Surgery With Extracorporeal Circulation: Role of Antithrombin Levels
Objective: To study the impact on postoperative costs of a patient's antithrombin levels associated with outcomes after cardiac surgery with extracorporeal circulation. Design: An analytic decision model was designed to estimate costs and clinical outcomes after cardiac surgery in a typical patient with low antithrombin levels (= 63.7%). The data used in the model were obtained from a literature review and subsequently validated by a panel of experts in cardiothoracic anesthesiology. Setting: Multi-institutional (14 Spanish hospitals). Participants: Consultant anesthesiologists. Measurements and Main Results: A sensitivity analysis of extreme scenarios was carried out to assess the impact o…
Enantioselective Protonation of the Lithium Transient Enolate of2-Methyltetralone with 2-Sulfinyl Alcohols
A new catalytic cycle for the enantioselective protonation of cyclic ketone enolates with sulfinyl alcohols has been developed. An enol trifluoroacetate that can be easily obtained from the corresponding ketone is used for the first time as an enolate precursor of a cyclic ketone enolate. In this method, the achiral alcohol plays two roles: it is involved, as is usual in catalytic asymmetric protonation reactions, in the turnover of the chiral proton source and also in the generation of a transient enolate through the reaction of its corresponding alkoxide with the enol trifluoroacetate precursor. Stereoselectivity is highly dependent on the structure of the achiral alcohol. High levels of …
An improved method for the asymmetric protonation of enolates with chiral α-sulfinyl alcohols/trifluoroethanol
Abstract Enantioselective protonation of 2-methyl tetralone enolate using a stoichiometric amount of 2-sulfinyl alcohol ( S , R s )- 1 as a chiral proton donor yields the corresponding chiral ketone with a high level of enantioselectivity, provided that the chiral proton donor (CPD) is regenerated with an achiral proton source (APS). In contrast, stereoselectivity was only moderate if catalytic CPD (0.2 equiv.) and an APS are used.
Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression.
Summary In the adult brain, continual neurogenesis of olfactory neurons is sustained by the existence of neural stem cells (NSCs) in the subependymal niche. Elimination of the cyclin-dependent kinase inhibitor 1A (p21) leads to premature exhaustion of the subependymal NSC pool, suggesting a relationship between cell cycle control and long-term self-renewal, but the molecular mechanisms underlying NSC maintenance by p21 remain unexplored. Here we identify a function of p21 in the direct regulation of the expression of pluripotency factor Sox2, a key regulator of the specification and maintenance of neural progenitors. We observe that p21 directly binds a Sox2 enhancer and negatively regulate…
La variabilidad en las mediciones ecográficas de la longitud céfalo-nalga y de la translucencia nucal. Problemas en un programa de cribado
Resumen Objetivo Describir como transcurre el aprendizaje en la medicion de la translucencia nucal (TN), la evolucion de la precision de las mediciones de esta y la de la longitud cefalo-nalga (LCN) durante la fase inicial de un programa de cribado y en los 2 anos posteriores de desarrollo. Material y metodos Fase de aprendizaje, basada en la discusion de la metodologia, la observacion de imagenes y en la practica no controlada de mediciones de la TN, analizada sobre 6 observadores en sus 100 primeras exploraciones. Evolucion de la precision de 3 observadores en las siguientes 3.601 ecografias. Analisis de las diferencias que se mantienen en las mediciones de la LCN y de la TN cuando los 3 …