0000000000424989

AUTHOR

Diana Horta

showing 3 related works from this author

Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study

2021

INTRODUCTION: Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement in placebo-controlled trials in patients with primary biliary cholangitis and insufficient response to ursodeoxycholic acid. There is scarce information outside of clinical trials. Therefore, we have assessed the effectiveness and adverse events of these treatments. METHODS: Data from patients included in the ColHai registry treated with OCA, fibrates, or both were recorded during a year, as well as adverse events and treatment discontinuation. RESULTS: Eighty-six patients were treated with OCA, 250 with fibrates (81% bezafibrate; 19% fenofibrate), and 15 with OCA plus fibrates. OCA group had baseli…

Malemedicine.medical_specialtyPROGNOSISChenodeoxycholic AcidPLACEBO-CONTROLLED TRIALGastroenterology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineFenofibrateInternal medicinemedicineHumansBIOCHEMICAL RESPONSEAdverse effectCIRRHOSISRetrospective StudiesFenofibrateBezafibrateHepatologybusiness.industryLiver Cirrhosis BiliaryGastroenterologyObeticholic acidMiddle AgedBEZAFIBRATEUrsodeoxycholic acideye diseasesDiscontinuationURSODEOXYCHOLIC ACIDClinical trialTreatment Outcomechemistry030220 oncology & carcinogenesisAlkaline phosphatase030211 gastroenterology & hepatologyFemaleBezafibratebusinessmedicine.drug
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Presentation and Outcomes of Pregnancy in Patients With Autoimmune Hepatitis

2018

Autoimmune hepatitis (AIH) frequently affects women of childbearing age in whom the desire to have a family raises the question regarding the potential risks for the fetus and the mother. The information on AIH in pregnant patients is scarce.1 The aims of this study were (1) to identify the risk factors associated with flares in pregnant patients diagnosed with AIH, (2) to determine the course of AIH in patients with pregnancy-related flares, and (3) to describe the outcome of AIH diagnosed in the postpartum period.

AdultPediatricsmedicine.medical_specialtyAutoimmune hepatitisCohort Studies03 medical and health sciences0302 clinical medicinePregnancyimmune system diseasesAzathioprinemedicineHumansIn patientAspartate AminotransferasesGlucocorticoidsreproductive and urinary physiologyRetrospective StudiesPregnancyHepatologybusiness.industryPostpartum PeriodPregnancy OutcomeGastroenterologyAlanine TransaminaseHypertension Pregnancy-InducedSymptom Flare Upmedicine.diseasedigestive system diseasesAbortion SpontaneousPregnancy ComplicationsDiabetes GestationalHepatitis Autoimmune030220 oncology & carcinogenesisChildbearing agePrednisoneDrug Therapy CombinationFemale030211 gastroenterology & hepatologyPresentation (obstetrics)businessImmunosuppressive AgentsPostpartum periodClinical Gastroenterology and Hepatology
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Analysis of the Association between Fatigue and the Plasma Lipidomic Profile of Inflammatory Bowel Disease Patients

2020

Inflammatory bowel disease (IBD) is a chronic, relapsing noninfectious inflammatory condition of the intestinal tract with two main phenotypes, ulcerative colitis (UC) and Crohn's disease (CD), and globally increasing incidence and prevalence. Nearly 80% of the IBD patients with active disease and 50% of those with inactive disease suffer fatigue with significant impairment of their quality of life. Fatigue has been associated with multiple factors in IBD patients but, in most cases, no direct cause can be identified, and risk factors in clinically quiescent IBD are contradictory. Furthermore, as the assessment of fatigue is subjective, there is an unmet clinical need for fatigue biomarkers…

BioquímicaBiologiamedicine.medical_specialtyDiseaseBiochemistryInflammatory bowel diseaseGastroenterology03 medical and health sciences0302 clinical medicineInternal medicineLipidomicsmedicineHumansFatigue030304 developmental biology0303 health sciencesCrohn's diseasebusiness.industryIncidence (epidemiology)General ChemistryInflammatory Bowel Diseasesmedicine.diseaseSphingolipidUlcerative colitis3. Good health030220 oncology & carcinogenesisLipidomicsQuality of LifeColitis UlcerativebusinessSphingomyelinJournal of Proteome Research
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