0000000000469113

AUTHOR

Michael O'donovan

showing 3 related works from this author

IS THE ERA OF CANDIDATE GENES X CANNABIS USE REALLY DEAD?

2019

Background: Historically, gene X environment examinations in psychotic disorders have employed candidate gene methods and environmental determinants impacting on similar biological mechanisms. However, genome wide association studies (GWAS) show that many variants associated with schizophrenia have a modest effect size on risk. In this respect, it is unclear whether the effect of cannabis on psychosis phenotypes is modified by a few genes, e.g. those involved in dopamine signalling, or by the overall genetic susceptibility to schizophrenia. Indeed, candidate gene approaches might be complementary to GWAS to test gene X cannabis interaction. We aimed to investigate the interactive effects of…

DRD2 psychosis genesSettore MED/25 - Psichiatria
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Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study

2019

The EUGEI project was supported by the grant agreement HEALTH-F2-2010-241909 from the European Community’s Seventh Framework Programme. The authors are grateful to the patients and their families for participating in the project. They also thank all research personnel involved in the GROUP project, in particular J. van Baaren, E. Veermans, G. Driessen, T. Driesen, E. van’t Hag and J. de Nijs. Bart PF Rutten was funded by a VIDI award number 91718336 from the Netherlands Scientific Organisation.

MalecannabisLogistic regression0302 clinical medicineLasso (statistics)Adverse Childhood ExperiencesStatisticsOdds RatioChild AbusePOLYGENIC RISKpsychosisChildPsychiatrySUMMER BIRTHFramingham Risk Score3. Good healthExposomePsychiatry and Mental healthmachine learningSchizophreniaArea Under CurveFemaleMarijuana UseSeasonsEnvironment And Schizophrenia—Feature Editor: Jim van OsLife Sciences & Biomedicineenvironmentpredictive modelingAdultExposomeDISORDERSrisk scoreYoung Adult03 medical and health sciencesPSYCHOSISmedicineJournal ArticleHumansHearing LossMETAANALYSISDEFICIT SCHIZOPHRENIAENVIRONMENTModels StatisticalScience & Technologychildhood traumaReceiver operating characteristicbusiness.industrySiblingsBullyingBayes TheoremChild Abuse SexualOdds ratiohearing impairmentmedicine.disease030227 psychiatryschizophreniaLogistic ModelsROC CurveSexual abuseCase-Control StudiesbusinessCHILDHOOD ADVERSITIES030217 neurology & neurosurgerywinter birth
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Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample…

2022

This work was supported by funding from the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). (...) CA was supported by the Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), Fundación Familia Alonso and Fundación Alicia Koplowitz. MB was supported by the Ministry of Economy and Competitivity (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – ERDF Funds from the European Commission, ‘A way of making Europ…

bipolar disorderAffective psychosisdiagnosisGENETIC-RELATIONSHIPSschizophrenia-spectrum disorderPsychiatry and Mental healthAffective psychosis bipolar disorder diagnosis genetics polygenic score psychosis psychotic depression schizophrenia-spectrum disorderLIABILITYpsychotic depressiongeneticspolygenic scorepsychosisGENOME-WIDE ASSOCIATIONApplied PsychologyPsychological Medicine
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