0000000000470947

AUTHOR

Pilar Pérez-romero

showing 5 related works from this author

Role of cytomegalovirus (CMV)-specific polyfunctional CD8+ T-cells and antibodies neutralizing virus epithelial infection in the control of CMV infec…

2015

The role of cytomegalovirus (CMV)-specific polyfunctional CD8+ T-cells and that of antibodies neutralizing virus epithelial infection (AbNEI) in the control of CMV DNAemia were investigated in 39 CMV-seropositive allogeneic stem-cell transplant (Allo-SCT) recipients with (n = 24) or without (n = 15) CMV DNAemia. AbNEI levels were monitored prospectively by means of a neutralization assay employing retinal epithelial cells (ARPE-19) and the recombinant CMV strain BADrUL131-Y4. Quantification of CMV-specific polyfunctional CD8+ T-cells (expressing two or three of the following markers: IFN-γγ, TNF-α and CD107a) in whole blood was performed by flow cytometry for intracellular cytokine staining…

AdultMaleCellular immunityCongenital cytomegalovirus infectionCytomegalovirusCD8-Positive T-LymphocytesAntibodies ViralEpitheliumVirusVirologymedicineHumansTransplantation HomologousCytotoxic T cellProspective StudiesViremiaAgedbiologyHematopoietic Stem Cell Transplantationvirus diseasesMiddle Agedmedicine.diseaseAntibodies NeutralizingVirologyTransplantationViral replicationCytomegalovirus InfectionsImmunologybiology.proteinFemaleAntibodyCD8Journal of General Virology
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Differences in cytomegalovirus plasma viral loads measured in allogeneic hematopoietic stem cell transplant recipients using two commercial real-time…

2010

5 páginas, 3 figuras.

medicine.medical_treatmentCongenital cytomegalovirus infectionCytomegalovirusHematopoietic stem cell transplantationHematopoietic stem cell transplantationBiologyPolymerase Chain ReactionAutomationPlasmaVirologymedicineHumansViral loadHematopoietic Stem Cell Transplantationvirus diseasesViral LoadUniversity hospitalmedicine.diseaseVirologyDNA extractionAllogeneic stem cell transplantReverse transcription polymerase chain reactionInfectious DiseasesReal-time polymerase chain reactionSpainImmunologyCytomegalovirus InfectionsAllogeneic hematopoietic stem cell transplantViral loadReal-time PCRJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology
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Comparison of the new Abbott Real Time CMV assay and the Abbott CMV PCR Kit for the quantitation of plasma cytomegalovirus DNAemia

2012

CMV DNA loads measured by the new Abbott RealTime CMV PCR were significantly higher than those quantitated by the Abbott CMV PCR kit (approximately 1 log(10)), and provided a better estimate of the actual CMV load present in plasma specimens as inferred by the use of the WHO standard.

Microbiology (medical)business.industryCongenital cytomegalovirus infectionCytomegalovirusvirus diseasesGeneral Medicinemedicine.diseasePolymerase Chain ReactionVirologylaw.inventionInfectious DiseasesReal-time polymerase chain reactionlawCytomegalovirus InfectionsDNA ViralLinear ModelsmedicineHumansCytomegalovirus infectionsDna viralbusinessPolymerase chain reactionDiagnostic Microbiology and Infectious Disease
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Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design

2015

Studies in transplant recipients over the past decade aiming to characterize the immune response to cytomegalovirus (CMV) replication have provided insights that can be used to guide CMV vaccine development. These studies have characterized multiple aspects of the immune response to virus infection in humans, and have identified immunologic variables that correlate with the ability to control virus replication. These findings can be used to guide vaccine development by informing decisions regarding antigen selection and the type of immune response that must be elicited by these antigens to promote protective immunity. In addition, these studies have provided information that could aid in th…

0301 basic medicinePharmacologymedicine.medical_specialtyViral Vaccine030106 microbiologyCongenital cytomegalovirus infectionViral VaccinesOrgan TransplantationBiologymedicine.diseaseVirusOrgan transplantationClinical trial03 medical and health sciences030104 developmental biologyImmune systemViral replicationAntigenTransplantation ImmunologyCytomegalovirus InfectionsDrug DiscoveryImmunologymedicineHumansAntigens ViralDrug Discovery Today
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Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations.

2016

Cytomegalovirus (CMV) infection remains a major complication of solid organ transplantation. Because of management of CMV is variable among transplant centers, in 2011 the Spanish Transplantation Infection Study Group (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) developed consensus guidelines for the prevention and treatment of CMV infection in solid organ transplant recipients. Since then, new publications have clarified or questioned the aspects covered in the previous document. For that reason, a panel of experts revised the evidence on CMV management, including immunological monitoring, diagnostics, prevention, vaccines, indirect effects, tre…

medicine.medical_specialtyCongenital cytomegalovirus infectionMEDLINEDrug resistance030230 surgeryAntiviral AgentsOrgan transplantation03 medical and health sciences0302 clinical medicineMonitoring ImmunologicMedicineHumansMajor complicationIntensive care medicineTransplantationbusiness.industryOrgan Transplantationmedicine.diseaseTransplant RecipientsCytomegalovirus infectionClinical microbiologyImmunologyCytomegalovirus InfectionsPractice Guidelines as Topic030211 gastroenterology & hepatologybusinessSolid organ transplantationTransplantation reviews (Orlando, Fla.)
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