6533b856fe1ef96bd12b1e77

RESEARCH PRODUCT

Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design

Angel Bulnes-ramosPilar Blanco-loboMichael J. McconnellDavid NavarroPilar Pérez-romero

subject

0301 basic medicinePharmacologymedicine.medical_specialtyViral Vaccine030106 microbiologyCongenital cytomegalovirus infectionViral VaccinesOrgan TransplantationBiologymedicine.diseaseVirusOrgan transplantationClinical trial03 medical and health sciences030104 developmental biologyImmune systemViral replicationAntigenTransplantation ImmunologyCytomegalovirus InfectionsDrug DiscoveryImmunologymedicineHumansAntigens Viral

description

Studies in transplant recipients over the past decade aiming to characterize the immune response to cytomegalovirus (CMV) replication have provided insights that can be used to guide CMV vaccine development. These studies have characterized multiple aspects of the immune response to virus infection in humans, and have identified immunologic variables that correlate with the ability to control virus replication. These findings can be used to guide vaccine development by informing decisions regarding antigen selection and the type of immune response that must be elicited by these antigens to promote protective immunity. In addition, these studies have provided information that could aid in the identification of immunologic endpoints in vaccine clinical trials, thus facilitating their design and implementation.

yearjournalcountryeditionlanguage
2015-12-11Drug Discovery Today
https://doi.org/10.1016/j.drudis.2016.03.005