L'encefalopatia epatica nella cirrosi epatica

-Correlation between deficiency of 25 (OH) vitamin D and liver damage in adult talassemic subjects

“The Linosa Study”: Epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate

Abstract Background and aims Growing evidence suggests that the metabolic syndrome (MetS) has both a genetic and environmental basis. To evaluate the possibility of a further genetic analysis, we estimated prevalence rates and heritabilities for the MetS and its individual traits in the adult population of Linosa, a small and isolated Italian Island in the southern-central part of the Mediterranean Sea. Methods and results The Linosa Study (LiS) group consisted of 293 Caucasian native subjects from 51 families (123 parents; 170 offsprings). The MetS was defined according to NCEP/ATP III criteria and the following prevalence rates were calculated: hyperglycaemia 20.3%; central obesity 34.9%;…

Bisphosphonate-associated femoral fracture: implication for management

Studies carried out on individuals being treated long term with bisphosphonates have provoked considerable interest and perplexity about the effect that these drugs have on bone turnover in the long run. In fact the experiences reported by numerous researchers tend to highlight how treatment with high doses of bisphosphonates over many years, of individuals with osteoporosis complicated by or secondary to neoplastic pathologies, causes a suppression of bone turnover that over time predisposes the bone to the accumulation of micro damage that can then result in complicated fractures, as in the case described here.

Swift observations of GRB 060614: an anomalous burst with a well behaved afterglow

GRB 060614 is a remarkable GRB observed by Swift with puzzling properties, which challenge current progenitor models. The lack of any bright SN down to very strict limits and the vanishing spectral lags are typical of short GRBs, strikingly at odds with the long (102s) duration of this event. Here we present spectral and temporal analysis of the Swift observations. We show that the burst presents standard optical, UV and X-ray afterglows. An achromatic break is observed simultaneously in optical and X-rays, at a time consistent with the break in the R-band light curve measured by the VLT. The achromatic behaviour and the consistent post-break decay slopes make GRB 060614 one of the best exa…

Is reduced baroreflex gain a component of the metabolic syndrome? Insights from the LINOSA study.

GRB 070311: a direct link between the prompt emission and the afterglow

We present prompt gamma-ray, early NIR/optical, late optical and X-ray observations of the peculiar GRB 070311 discovered by INTEGRAL, in order to gain clues on the mechanisms responsible for the prompt gamma-ray pulse as well as for the early and late multi-band afterglow of GRB 070311. We fitted with empirical functions the gamma-ray and optical light curves and scaled the result to the late time X-rays. The H-band light curve taken by REM shows two pulses peaking 80 and 140 s after the peak of the gamma-ray burst and possibly accompanied by a faint gamma-ray tail. Remarkably, the late optical and X-ray afterglow underwent a major rebrightening between 3x10^4 and 2x10^5 s after the burst …

The flaring afterglow of GRB 050730

We present a detailed spectral and temporal analysis of Swift and XMM-Newton observations of GRB 050730. The X-ray afterglow of GRB 050730 was found to decline with time with intense flaring activity superimposed. Evidence of flaring activity in the early UVOT optical afterglow, simultaneous with that observed in the X-ray band, was found. Strong spectral evolution in the X-ray energy band during the flaring activity was present.

IL GENE PCSK9: UN NUOVO GENE IMPLICATO NEL CONTROLLO DELLA COLESTEROLEMIA

The distribution of cholesterol plasma is regulated by complex interactions between genes and environmental factors. Mutations of PCSK9 gene seem to modulate the levels of LDL-C. Mutations of PCSK9 gene with gain of function are associated to hypercholesterolemia and mutations with loss of function determine hypocholesterolemia.

Rest frame light curves of Swift GRBs

Chemioterapia di II linea nel carcinoma epiteliale dell'ovaio. Studio di Fase II

Chemioterapia di II linea nel carcinoma epiteliale dell'ovaio. Studio di Fase II.

Effects of mud-pack treatment on plasma cytokine and soluble adhesion molecule levels in healthy volunteers

Abstract Background : The suggested hypothesis of a direct anti-inflammatory property of mud-pack treatment has led us to speculate that its action on the cytokine network might counteract the heat-stress-related effects on platelet and endothelial cell function often reported following hot-spring baths. Therefore, the present study was designed to investigate the effects of a cycle of 12 daily mud-pack treatments on bio-humoral markers of inflammation, as well as on markers of in vivo platelet and/or endothelial cell activation, in plasma samples obtained from healthy volunteers. Methods : Blood samples were obtained before ( T 0 ), at the end of the first treatment ( T 1 ) and after a cyc…

Correlation between deficiency of 25 (OH) vitamin D, bone mineral density and markers of bone turnover in sicialian postmenopausal womens

The exceptionally extended flaring activity in the X-ray afterglow of GRB 050730 observed with Swift and XMM-Newton

We present the results of a detailed spectral and temporal analysis of Swift and XMM-Newton observations of the high redshift (z=3.969) GRB 050730. The X-ray afterglow of GRB 050730 was found to decline with time with superimposed intense flaring activity that extended over more than two orders of magnitude in time. Seven distinct re-brightening events starting from 236 s up to 41.2 ks after the burst were observed. The underlying decay of the afterglow was well described by a double broken power-law model with breaks at t_1= 237 +/- 20 s and t_2 = 10.1 (-2.2) (+4.6) ks. The temporal decay slopes before, between and after these breaks were alpha_1 = 2.1 +/- 0.3, alpha_2 = 0.44 (-0.08) (+0.1…

Swift Observations of GRB 070110: An Extraordinary X-Ray Afterglow Powered by the Central Engine

We present a detailed analysis of Swift multi-wavelength observations of GRB 070110 and its remarkable afterglow. The early X-ray light curve, interpreted as the tail of the prompt emission, displays a spectral evolution already seen in other gamma-ray bursts. The optical afterglow shows a shallow decay up to ~2 d after the burst, which is not consistent with standard afterglow models. The most intriguing feature is a very steep decay in the X-ray flux at ~20 ks after the burst, ending an apparent plateau. The abrupt drop of the X-ray light curve rules out an external shock as the origin of the plateau in this burst and implies long-lasting activity of the central engine. The temporal and s…

FokI Polymorphism of the Vitamin D Receptor Gene Correlates with Parameters of Bone Mass and Turnover in a Female Population of the Italian Island of Lampedusa

One of the most promising genetic approaches to dissecting a multifactorial disease is represented by genetically isolated population studies. We studied a genetic marker in a cohort of women living on the Mediterranean island of Lampedusa, a geographically isolated population. Lampedusa, located between the African coast and Sicily, consists of a young genetic isolate (<20 generations) with an exponential growth in the last generations. We analyzed the association between the FokI vitamin D receptor (VDR) gene polymorphism, previously proposed as a predictor of bone mass, with parameters of bone mass and turnover in a cohort of pre- and postmenopausal women living on Lampedusa. In 424 wome…

Studio di Fase II con Gemcitabina + oxaliplatino in combinazione nel trattamento delle neoplasie delle vie biliari, pancreas e colecisti in fase metastatica.

Studio di Fase II con Gemcitabina + oxaliplatino in combinazione nel trattamento delle neoplasie delle vie biliari, pancreas e colecisti in fase metastatica.

Le ipocolesterolemie primitive

Hypobetalipoproteinemia (HBL) is characterized by cholesterol levels below the 5th percentile of the population distribution. Familial HBL (FHBL) is characterized by an inherited HBL trait within a family. In the last years gene defects underlying some cases of FHBL, but not all, have been identified. The molecular basis of some gene defect and the clinical onset of FHBL are presented in this paper.

LE IPERCOLESTEROLEMIE PRIMITIVE

Heparin induces an accumulation of atherogenic lipoproteins during hemodialysis in normolipidemic end-stage renal disease patients

Dyslipidemias may account for the excess of cardiovascular mortality in end-stage renal disease (ESRD). Lipoprotein studies in ESRD patients are usually relative to prehemodialysis samples even if significative changes may occur after dialysis. In this study, we aimed to investigate the effects of ESRD on triglyceride-rich lipoproteins (TRL) subpopulations distribution and acute change following hemodialytic procedures, including the relative contribution of heparin administration. We selected a group of normolipidemic male middle-aged ESRD patients free of any concomitant disease affecting lipoprotein remnant metabolism compared with controls. We separated TRL subfractions according to den…

Effetto del polimorfismo genico del gene CYP1B1 sul metabolismo estrogenino e sulla densità ossea

Heritabilities of the metabolic syndrome and its component traits in a caucasian genetic isolate

GRB 061121: Broadband Spectral Evolution through the Prompt and Afterglow Phases of a Bright Burst

Swift triggered on a precursor to the main burst of GRB 061121 (z=1.314), allowing observations to be made from the optical to gamma-ray bands. Many other telescopes, including Konus-Wind, XMM-Newton, ROTSE and the Faulkes Telescope North, also observed the burst. The gamma-ray, X-ray and UV/optical emission all showed a peak ~75s after the trigger, although the optical and X-ray afterglow components also appear early on - before, or during, the main peak. Spectral evolution was seen throughout the burst, with the prompt emission showing a clear positive correlation between brightness and hardness. The Spectral Energy Distribution (SED) of the prompt emission, stretching from 1eV up to 1MeV…

Studio di fase II con Gemcitabine + Oxaliplatino in combinazione nel trattamento delle neoplasie delle vie biliari, pancreas e colecisti in fase metastatica.