0000000000497513

AUTHOR

Premysl Bercik

showing 3 related works from this author

The Risk of Contracting COVID-19 Is Not Increased in Patients With Celiac Disease

2021

The World Health Organization declared coronavirus disease-2019 (COVID-19) a global pandemic in March 2020. Since then, there are more than 34 million cases of COVID-19 leading to more than 1 million deaths worldwide. Numerous studies suggest that celiac disease (CeD), a chronic immune-mediated gastrointestinal condition triggered by gluten, is associated with an increased risk of respiratory infections.(1-3) However, how it relates to the risk of COVID-19 is unknown. To address this gap, we conducted a cross-sectional study to evaluate whether patients with self-reported CeD are at an increased risk of contracting COVID-19.

AdultMalePediatricsmedicine.medical_specialtySettore MED/09 - Medicina InternaCoronavirus disease 2019 (COVID-19)coronavirusDiseasemedicine.disease_causeArticle03 medical and health sciencesDiet Gluten-Free0302 clinical medicineRisk FactorsSurveys and QuestionnairesPandemicOdds RatioMedicineHumansIn patientCoronavirusriskHepatologybusiness.industrySARS-CoV-2Case-control studyGastroenterologyCOVID-19Odds ratioinfectionCeliac Disease030220 oncology & carcinogenesisCase-Control Studiesgluten030211 gastroenterology & hepatologyGluten freeFemalebusiness
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Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins.

2019

Background & Aims Wheat-related disorders, a spectrum of conditions induced by the ingestion of gluten-containing cereals, have been increasing in prevalence. Patients with celiac disease have gluten-specific immune responses, but the contribution of non-gluten proteins to symptoms in patients with celiac disease or other wheat-related disorders is controversial. Methods C57BL/6 (control), Myd88–/–, Ticam1–/–, and Il15–/– mice were placed on diets that lacked wheat or gluten, with or without wheat amylase trypsin inhibitors (ATIs), for 1 week. Small intestine tissues were collected and intestinal intraepithelial lymphocytes (IELs) were measured; we also investigated gut permeability and int…

0301 basic medicineInflammationdigestive systemSensitivity and SpecificityGliadin03 medical and health sciencesDiet Gluten-FreeMiceRandom Allocation0302 clinical medicineImmune systemReference ValuesLactobacillusmedicineAnimalsHumansAmylaseTriticum2. Zero hungerchemistry.chemical_classificationToll-like receptorHepatologybiologybusiness.industryGastroenterologynutritional and metabolic diseasesbiology.organism_classificationGlutendigestive system diseasesSmall intestineImmunity Innate3. Good healthGastrointestinal MicrobiomeMice Inbred C57BLCeliac DiseaseDisease Models AnimalLactobacillus030104 developmental biologymedicine.anatomical_structurechemistryImmunologyAmylasesbiology.proteinIntraepithelial lymphocyte030211 gastroenterology & hepatologymedicine.symptombusinessTrypsin InhibitorsGastroenterology
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Gluten-Free Diet Reduces Symptoms, Particularly Diarrhea, in Patients With Irritable Bowel Syndrome and Antigliadin IgG

2021

Background & Aims Many patients with irritable bowel syndrome (IBS) perceive that their symptoms are triggered by wheat-containing foods. We assessed symptoms and gastrointestinal transit before and after a gluten-free diet (GFD) in unselected patients with IBS and investigated biomarkers associated with symptoms. Methods We performed a prospective study of 50 patients with IBS (ROME III, all subtypes), with and without serologic reactivity to gluten (antigliadin IgG and IgA), and 25 healthy subjects (controls) at a university hospital in Hamilton, Ontario, Canada, between 2012 and 2016. Gastrointestinal transit, gut symptoms, anxiety, depression, somatization, dietary habits, and microbiot…

Diarrheamedicine.medical_specialtyAbdominal painConstipationGastroenterologyIrritable Bowel SyndromeDiet Gluten-Free03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansProspective StudiesIrritable bowel syndromechemistry.chemical_classificationCrohn's diseaseHepatologybusiness.industryGastroenterologymedicine.disease3. Good healthCeliac DiseaseDiarrheachemistryImmunoglobulin G030220 oncology & carcinogenesis030211 gastroenterology & hepatologyGluten freemedicine.symptombusinessFODMAPSomatizationClinical Gastroenterology and Hepatology
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