Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the i…

Italy GIDEON final analysis Sorafenib-treated patients: prognostic value of baseline characteristics and staging systems

Toward an update of the structural model in Italian submerged areas: contributions from the EMODnet Geology Project

The European Marine Observation and Data Network (EMODNet) Project aims at the collection of as many existing data as possible on European Seas to be represented on digital maps at the 1:250,000 scale, accessible via web through a dedicated portal. It is articulated into different Lots concerning Bathymetry, Geology, Biology, Chemistry, Physics, Physical Habitats, Human activities. The Geology Lot is realized by a Consortium in which the Geological Survey of Italy is partner. EMODnet Geology requires the compilation of a number of layers subdivided into Work Packages (WP), referring to seafloor sediments grainsize, sedimentation rates, Quaternary geology, pre-Quaternary geology and stratigr…

Parametri sierologici e cellulari della specie alloctona Procambarus clarckii

Procambarus clarkii è un animale d’acqua dolce originario del Centro-Sud degli Stati Uniti e del Nord-Est del Messico. Questa specie rientra nella lista delle 100 specie invasive più pericolose al mondo (Delivering Alien Invasive Species Inventories for Europe) in quanto presenta una serie di caratteristiche biologiche, che la rendono una minaccia per la biodiversità. In Sicilia la sua presenza è stata registrata per la prima volta nel 2003 nella riserva naturale “Lago Preola e Gorghi Tondi”, Mazara del Vallo (TP). Allo scopo di conoscere meglio la biologia di questa specie, su esemplari di P. clarkii provenienti dalla riserva di Trapani, abbiamo esaminato i tipi emocitari ed alcune attivit…

Mapping tectonics: a key element in submarine geological events and probabilities assessment