The unusual multiwavelength properties of the gamma-ray source PMN J1603-4904

We investigate the nature and classification of PMNJ1603-4904, a bright radio source close to the Galactic plane, which is associated with one of the brightest hard-spectrum gamma-ray sources detected by Fermi/LAT. It has previously been classified as a low-peaked BL Lac object based on its broadband emission and the absence of optical emission lines. Optical measurements, however, suffer strongly from extinction and the absence of pronounced short-time gamma-ray variability over years of monitoring is unusual for a blazar. We are combining new and archival multiwavelength data in order to reconsider the classification and nature of this unusual gamma-ray source. For the first time, we stud…

Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort.

Obstructive sleep apnea (OSA) and asthma are often associated and several studies suggest a bidirectional relationship between asthma and OSA. This study analyzed the characteristics of patients with suspected OSA from the European Sleep Apnea Database according to presence/absence of physician-diagnosed asthma. Cross-sectional data in 16,236 patients (29.1% female) referred for suspected OSA were analyzed according to occurrence of physician-diagnosed asthma for anthropometrics, OSA severity and sleepiness. Sleep structure was assessed in patients studied by polysomnography (i.e. 48% of the sample). The prevalence of physician-diagnosed asthma in the entire cohort was 4.8% (7.9% in women, …

Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

The TANAMI Multiwavelength Program: Dynamic spectral energy distributions of southern blazars

We thank the referee for helpful comments. We thank S. Cutini for her useful comments. We thank S. Markoff for helpful discussions. We thank J. Perkins, L. Baldini, and S. Digel for carefully reading the manuscript. We thank M. Buxton for her help with the SMARTS data. We acknowledge support and partial funding by the Deutsche Forschungsgemeinschaft grant WI 1860-10/1 (TANAMI) and GRK 1147, Deutsches Zentrum fur Luft- und Raumfahrt grants 50 OR 1311 and 50 OR 1103, and the Helmholtz Alliance for Astroparticle Physics (HAP). This research was funded in part by NASA through Fermi Guest Investigator grants NNH09ZDA001N, NH10ZDA001N, NNH12ZDA001N, and NNH13ZDA001N-FERMI. This research was suppo…

Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analyse…

ANTARES constrains a blazar origin of two IceCube PeV neutrino events

Abstract Context. The source(s) of the neutrino excess reported by the IceCube Collaboration is unknown. The TANAMI Collaboration recently reported on the multiwavelength emission of six bright, variable blazars which are positionally coincident with two of the most energetic IceCube events. Objects like these are prime candidates to be the source of the highest-energy cosmic rays, and thus of associated neutrino emission. Aims. We present an analysis of neutrino emission from the six blazars using observations with the ANTARES neutrino telescope. Methods. The standard methods of the ANTARES candidate list search are applied to six years of data to search for an excess of muons and hence th…

TANAMI Blazars in the IceCube PeV Neutrino Fields

The IceCube Collaboration has announced the discovery of a neutrino flux in excess of the atmospheric background. Due to the steeply falling atmospheric background spectrum, events at PeV energies are most likely of extraterrestrial origin. We present the multiwavelength properties of the six radio brightest blazars positionally coincident with these events using contemporaneous data of the TANAMI blazar sample, including high-resolution images and spectral energy distributions. Assuming the X-ray to {\gamma}-ray emission originates in the photoproduction of pions by accelerated protons, the integrated predicted neutrino luminosity of these sources is large enough to explain the two detecte…

GENETIC ASPECTS OF HYPERTENSION AND METABOLIC DISEASE IN THE OBSTRUCTIVE SLEEP APNOEA-HYPOPNOEA SYNDROME.

Considerable evidence is available in support of an independent association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular disease, which is particularly strong for systemic arterial hypertension and growing for ischaemic heart disease, stroke, heart failure, atrial fibrillation and cardiac sudden death. The pathogenesis of cardiovascular disease in OSAS is not completely understood but likely to be multifactorial, involving a diverse range of mechanisms including sympathetic nervous system overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormal coagulation and metabolic dysregulation, the latter particularly involving in…

A Highly Magnetized Twin-Jet Base Pinpoints a Supermassive Black Hole

Supermassive black holes (SMBH) are essential for the production of jets in radio-loud active galactic nuclei (AGN). Theoretical models based on Blandford & Znajek extract the rotational energy from a Kerr black hole, which could be the case for NGC1052, to launch these jets. This requires magnetic fields of the order of $10^3\,$G to $10^4\,$G. We imaged the vicinity of the SMBH of the AGN NGC1052 with the Global Millimetre VLBI Array and found a bright and compact central feature, smaller than 1.9 light days (100 Schwarzschild radii) in radius. Interpreting this as a blend of the unresolved jet bases, we derive the magnetic field at 1 Schwarzschild radius to lie between 200 G and ~8000…

Future mmVLBI Research with ALMA: a European vision

Very long baseline interferometry at millimetre/submillimetre wavelengths (mmVLBI) offers the highest achievable spatial resolution at any wavelength in astronomy. The anticipated inclusion of ALMA as a phased array into a global VLBI network will bring unprecedented sensitivity and a transformational leap in capabilities for mmVLBI. Building on years of pioneering efforts in the US and Europe the ongoing ALMA Phasing Project (APP), a US-led international collaboration with MPIfR-led European contributions, is expected to deliver a beamformer and VLBI capability to ALMA by the end of 2014 (APP: Fish et al. 2013, arXiv:1309.3519). This report focuses on the future use of mmVLBI by the intern…

Sub-milliarcsecond imaging of a bright flare and ejection event in the extragalactic jet 3C 111

Context. Flares in radio-loud active galactic nuclei are thought to be associated with the injection of fresh plasma into the compact jet base. Such flares are usually strongest and appear earlier at shorter radio wavelengths. Hence, very long baseline interferometry (VLBI) at millimeter(mm)-wavelengths is the best-suited technique for studying the earliest structural changes of compact jets associated with emission flares. Aims. We study the morphological changes of the parsec-scale jet in the nearby (z = 0.049) γ-ray bright radio galaxy 3C 111 following a flare that developed into a major radio outburst in 2007. Methods. We analyse three successive observations of 3C 111 at 86 GHz with th…

TANAMI: Tracking Active Galactic Nuclei with Austral Milliarcsecond Interferometry - II. Additional Sources

TANAMI is a multiwavelength program monitoring active galactic nuclei (AGN) south of -30deg declination including high-resolution Very Long Baseline Interferometry (VLBI) imaging, radio, optical/UV, X-ray and gamma-ray studies. We have previously published first-epoch 8.4GHz VLBI images of the parsec-scale structure of the initial sample. In this paper, we present images of 39 additional sources. The full sample comprises most of the radio- and gamma-ray brightest AGN in the southern quarter of the sky, overlapping with the region from which high-energy (>100TeV) neutrino events have been found. We characterize the parsec-scale radio properties of the jets and compare with the quasi-simu…

First Multi-wavelength Campaign on the Gamma-ray-loud Active Galaxy IC 310

The extragalactic VHE gamma-ray sky is rich in blazars. These are jetted active galactic nuclei viewed at a small angle to the line-of-sight. Only a handful of objects viewed at a larger angle are known so far to emit above 100 GeV. Multi-wavelength studies of such objects up to the highest energies provide new insights into the particle and radiation processes of active galactic nuclei. We report the results from the first multi-wavelength campaign observing the TeV detected nucleus of the active galaxy IC 310, whose jet is observed at a moderate viewing angle of 10 deg - 20 deg. The multi-instrument campaign was conducted between 2012 Nov. and 2013 Jan., and involved observations with MAG…

Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

WOS: 000482433800011

Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Abstract.Gunduz C, Basoglu OK, Hedner J, et al; onbehalf of the European Sleep Apnoea Databasecollaborators (Biruni University; Ege University;Gothenburg University; Sahlgrenska UniversityHospital; University of Palermo; CNR Institute ofBiomedicine and Molecular Immunology; St. AdolfStift; Hospital de Santa Maria; University of Crete;Antoine-Beclere Hospital; G. PapanikolaouHospital; Institute of Tuberculosis and LungDiseases; University Hospital Brno; St. Ann’sUniversity Hospital; Universite ́ Grenoble Alpes)Hyperlipidaemia prevalence and cholesterolcontrol in obstructive sleep apnoea: Data from theEuropean sleep apnea database (ESADA).J InternMed2019;286: 676–688.Background and objective.…

Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

[No abstract available]

Consequences of a possible jet-star interaction in the inner central parsec of Centaurus A

The jet-counterjet system of the closest radio-loud active galaxy Centaurus A (Cen A) can be studied with Very Long Baseline Interferometry (VLBI) on unprecedented small linear scales of ~0.018pc. These high-resolution observations provide essential information on jet emission and propagation within the inner parsec of an AGN jet. We present the results of a kinematic study performed within the framework of the Southern-hemisphere AGN monitoring program TANAMI. Over 3.5years, the evolution of the central-parsec jet structure of Cen A was monitored with VLBI. These observations reveal complex jet dynamics which are well explained by a spine-sheath structure supported by the downstream accele…

Single-Dish Radio Polarimetry in the F-GAMMA Program with the Effelsberg 100-m Radio Telescope

Studying the variability of polarized AGN jet emission in the radio band is crucial for understanding the dynamics of moving shocks as well as the structure of the underlying magnetic field. The 100-m Effelsberg Telescope is a high-quality instrument for studying the long-term variability of both total and polarized intensity as well as the electric-vector position angle. Since 2007, the F-GAMMA program has been monitoring the linear polarized emission of roughly 60 blazars at 11 frequencies between 2.7 and 43 GHz. Here, we describe the calibration of the polarimetric data at 5 and 10 GHz and the resulting F-GAMMA full-Stokes light curves for the exemplary case of the radio galaxy 3C 111.

Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profil…

Millimeter VLBI of NGC 1052: Dynamics

The LINER galaxy NGC 1052 is an ideal target to study the innermost regions of active galactic nuclei (AGN), given its close distance of about 20 Mpc. The source was observed at 29 epochs from 2005 to 2009 with the Very Long Baseline Array (VLBA) at 43 GHz. Here, we present a kinematic study of its twin-jet system from a subset of 9 epochs at 43 GHz carried out in 2005 and 2006, finding a bright central feature as the dynamic center. The resulting mean velocities of β = v / c = 0 . 46 ± 0 . 08 and β = 0 . 69 ± 0 . 02 for the western and eastern jet, respectively, give hints towards higher velocities in the eastern jet.

The EVN view of the highly variable TeV active galaxy IC 310

Very-high-energy $\gamma$-ray observations of the active galaxy IC 310 with the MAGIC telescopes have revealed fast variability with doubling time scales of less than 4.8min. This implies that the emission region in IC 310 is smaller than 20% of the gravitational radius of the central supermassive black hole with a mass of $3\times 10^8 M_\odot$, which poses serious questions on the emission mechanism and classification of this enigmatic object. We report on the first quasi-simultaneous multi-frequency VLBI observations of IC 310 conducted with the EVN. We find a blazar-like one-sided core-jet structure on parsec scales, constraining the inclination angle to be less than $\sim 20^\circ$ but…

Black hole lightning due to particle acceleration at subhorizon scales

Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry, but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here, we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC telescopes revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20\% of the gravitational radius of its central black hole. We suggest that the emission is associated …

Coincidence of a high-fluence blazar outburst with a PeV-energy neutrino event

The discovery of extraterrestrial very-high-energy neutrinos by the IceCube collaboration has launched a quest for the identification of their astrophysical sources. Gamma-ray blazars have been predicted to yield a cumulative neutrino signal exceeding the atmospheric background above energies of 100 TeV, assuming that both the neutrinos and the gamma-ray photons are produced by accelerated protons in relativistic jets. Since the background spectrum falls steeply with increasing energy, the individual events with the clearest signature of being of an extraterrestrial origin are those at PeV energies. Inside the large positional-uncertainty fields of the first two PeV neutrinos detected by Ic…

The gamma-ray emitting radio-loud narrow-line Seyfert 1 galaxy PKS 2004-447 I. The X-ray View

As part of the TANAMI multiwavelength progam, we discuss new X-ray observations of the $\gamma$-ray and radio-loud Narrow Line Seyfert galaxy ($\gamma$-NLS1) PKS 2004-447. The active galaxy is a member of a small sample of radio-loud NLS1s detected in $\gamma$-rays by the Fermi Large Area Telescope. It is the radio-loudest and only southern-hemisphere source in this sample. We present results from our X-ray monitoring program comprised of Swift snapshot observations from 2012 through 2014 and two new X-ray observations with XMM-Newton in 2012. We analyze the X-ray spectrum and variability of this peculiar source using supplementary archival data from 2004 and 2011. The (0.5-10) keV spectrum…

TANAMI monitoring of Centaurus A: The complex dynamics in the inner parsec of an extragalactic jet

Centaurus A is the closest radio-loud active galaxy. Very Long Baseline Interferometry (VLBI) enables us to study the jet-counterjet system on milliarcsecond (mas) scales, providing essential information for jet emission and propagation models. We study the evolution of the central parsec jet structure of Cen A over 3.5 years. The proper motion analysis of individual jet components allows us to constrain jet formation and propagation and to test the proposed correlation of increased high energy flux with jet ejection events. Cen A is an exceptional laboratory for such detailed study as its proximity translates to unrivaled linear resolution, where 1 mas corresponds to 0.018 pc. The first 7 …

Dynamic SEDs of southern blazars - DSSB

The Dynamic SEDs of southern blazars catalog is based on a TANAMI multiwavelength project that has been monitoring a sample of 22 radio-loud blazars of the southern sky from radio to gamma-ray wavelengths. (4 data files). Simultaneous broadband spectral and temporal studies of blazars are an important tool for investigating active galactic nuclei (AGN) jet physics. Aims. We study the spectral evolution between quiescent and flaring periods of 22 radio-loud AGN through multiepoch, quasi-simultaneous broadband spectra. For many of these sources these are the first broadband studies. Methods. We use a Bayesian block analysis of Fermi/LAT light curves to determine time ranges of constant flux f…

TANAMI II. Additional sources

TANAMI is a multiwavelength program monitoring active galactic nuclei (AGN) south of -30{deg} declination including high-resolution Very Long Baseline Interferometry (VLBI) imaging, radio, optical/UV, X-ray and {gamma}-ray studies. We have previously published first-epoch 8.4GHz VLBI images of the parsec-scale structure of the initial sample. In this paper, we present images of 39 additional sources. The full sample comprises most of the radio- and {gamma}-ray brightest AGN in the southern quarter of the sky, overlapping with the region from which high-energy (>100TeV) neutrino events have been found. We characterize the parsec-scale radio properties of the jets and compare with the quasi-s…