0000000000515145
AUTHOR
Carlos Argente
Estudio de receptor anómalo suprarrenal en sujetos con síndrome de Cushing ACTH-independiente e hiperplasia nodular suprarrenal
Resumen Introduccion El sindrome de Cushing ACTH-independiente (SCAI) supone el 15-20% de los casos de sindrome de Cushing, de los cuales Material y metodos Estudio descriptivo multicentrico de una serie de 15 casos de SCAI con hiperplasia nodular suprarrenal (periodo de estudio: 2002-2016). En ellos se hizo el despistaje de receptor anomalo, mediante pruebas de estimulacion, considerando patologico un aumento de cortisol plasmatico ≥ del 25% respecto al valor basal. Resultados De los 15 casos, 13 fueron mujeres, con una edad media al diagnostico de 56,8 anos. En 12 de los 15 casos estudiados se detecto positividad de las pruebas de estimulacion. De ellos, fueron positivos para comida de pr…
Misclassification of subjects with insulin resistance and associated cardiovascular risk factors by homeostasis model assessment index. Utility of a postprandial method based on oral glucose tolerance test
Different methods are available for assessing insulin sensitivity in the fasting state. However, insulin resistance (IR) is initially a postprandial disturbance; and usually, when basal (fasting) disturbance appears, the process has been in progress for some time. Our aim was to investigate if a postprandial measurement, performing an oral glucose tolerance test (OGTT), is more sensitive than fasting values. We wished to identify early IR states in healthy, nonobese individuals and ascertain if this situation was associated with other cardiovascular risk factors. A total of 90 nonobese, nondiabetic, and nonsmoker individuals were studied. They were divided into 3 groups according to IR stat…
Study of abnormal adrenal receptors in subjects with ACTH-independent Cushing's syndrome and nodular adrenal hyperplasia
ACTH-independent Cushing's Syndrome (AICS) accounts for 15-20% of cases of Cushing's syndrome, with1% due to abnormal receptors. Our aim is to study the presence of abnormal receptors in subjects diagnosed with AICS with nodular adrenal hyperplasia in a 14-year period (2002-2016), as well as its clinical-biological and evolutive characteristics.A multicentre descriptive study of a 15-case series of AICS with nodular adrenal hyperplasia (study period: 2002-2016). In these cases, abnormal receptor screening was performed by means of stimulation tests, with a plasma cortisol increase of ≥ 25% from baseline being considered pathologic.Of the 15 cases, 13 were female, with a mean age at diagnosi…