0000000000524566

AUTHOR

Ichiko Saotome

showing 3 related works from this author

β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche

2014

Coordinated Hair Growth Wnt/β-catenin signaling is a key pathway that plays a conserved role in regulating stem cell function during adult tissue regeneration. Using time-lapse imaging of live mice, Deschene et al. (p. 1353 ) show that genetic activation of β-catenin within hair follicle stem cells generates axes of hair growth by coordinated cell divisions and cell movements, even when the normal niches—the dermal papillae—are laser-ablated. Activated β-catenin enhances Wnt ligand secretion, and these ligands can then activate Wnt signaling in adjacent cells that do not have activated β-catenin, indicating how activated stem cells could influence neighboring cells during normal growth and …

Beta-cateninWnt ProteinCellular differentiationLigandBiologyLigandsModels BiologicalArticleMiceStem CellmedicineAnimalsStem Cell NicheAnimals; Cell Differentiation; Cell Division; Hair; Hair Follicle; Ligands; Mice; Models Biological; Mutation; Stem Cell Niche; Stem Cells; Tamoxifen; Up-Regulation; Wnt Proteins; beta Catenin; Wnt Signaling Pathway; Medicine (all); MultidisciplinaryWnt Signaling Pathwaybeta CateninMultidisciplinaryintegumentary systemAnimalStem CellsMedicine (all)Regeneration (biology)Mesenchymal stem cellWnt signaling pathwayCell DifferentiationHair follicleUp-RegulationCell biologyWnt ProteinsTamoxifenmedicine.anatomical_structureCateninMutationbiology.proteinStem cellHair FollicleCell DivisionHairScience
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Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk

2014

A fundamental goal in cancer biology is to identify the cells and signalling pathways that are keys to induce tumour regression. Here we use a spontaneously self-regressing tumour, cutaneous keratoacanthoma (KAs), to identify physiological mechanisms that drive tumour regression. By using a mouse model system that recapitulates the behaviour of human KAs, we show that self-regressing tumours shift their balance to a differentiation programme during regression. Furthermore, we demonstrate that developmental programs utilized for skin hair follicle regeneration, such as Wnt, are hijacked to sustain tumour growth and that the retinoic acid (RA) signalling pathway promotes tumour regression by …

KeratoacanthomaSkin NeoplasmsRemission SpontaneousRetinoic acidGeneral Physics and AstronomyTretinoinBiologyGeneral Biochemistry Genetics and Molecular BiologyArticle03 medical and health scienceschemistry.chemical_compoundMicePhysics and Astronomy (all)0302 clinical medicineTretinoinStem CellmedicineAnimalsSkin NeoplasmRemission SpontaneouWnt Signaling PathwayAnimals; Carcinoma Squamous Cell; Disease Models Animal; Hair Follicle; Keratoacanthoma; Mice; Remission Spontaneous; Skin Neoplasms; Stem Cells; Tretinoin; Wnt Signaling Pathway; Chemistry (all); Biochemistry Genetics and Molecular Biology (all); Physics and Astronomy (all)030304 developmental biology0303 health sciencesMultidisciplinaryBiochemistry Genetics and Molecular Biology (all)AnimalRegeneration (biology)Stem CellsChemistry (all)Wnt signaling pathwayGeneral Chemistrymedicine.diseaseHair follicleHedgehog signaling pathwayDisease Models AnimalKeratoacanthomamedicine.anatomical_structurechemistry030220 oncology & carcinogenesisImmunologyCancer researchCarcinoma Squamous CellStem cellHair Folliclemedicine.drug
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Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

2012

Tissue development and regeneration depend on cell-cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properly regenerated tissue are not well understood. Using a new, non-invasive, intravital two-photon imaging approach we study physiological hair-follicle regeneration over time in live mice. By these means we have monitored the behaviour of epithelial stem cells and their progeny during physiological hair regeneration and addressed how the mesenchyme influences their behaviour. Consistent with earlier studies, stem cells are quiescent during the initial stages of hair regeneration, whereas the progeny are more …

MesodermCell divisionCell SurvivalMesenchymeMice TransgenicBiologyArticleMesodermMiceCell MovementStem CellLive cell imagingmedicineAnimalsRegenerationMultidisciplinaryintegumentary systemAnimalStem CellsMedicine (all)Regeneration (biology)DermisHair follicleCell biologyMicroscopy Fluorescence Multiphotonmedicine.anatomical_structureAnimals; Cell Division; Cell Movement; Cell Survival; Cell Tracking; Dermis; Hair Follicle; Laser Therapy; Mesoderm; Mice; Mice Transgenic; Microscopy Fluorescence Multiphoton; Regeneration; Stem Cells; Medicine (all); MultidisciplinaryCell TrackingDermiLaser TherapyStem cellHair FollicleDevelopmental biologyCell DivisionNature
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