6533b823fe1ef96bd127e27c

RESEARCH PRODUCT

β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche

Peggy MyungGiovanni ZitoThomas Yang SunMakoto Mark TaketoValentina GrecoElizabeth R. DeschenePanteleimon RompolasIchiko Saotome

subject

Beta-cateninWnt ProteinCellular differentiationLigandBiologyLigandsModels BiologicalArticleMiceStem CellmedicineAnimalsStem Cell NicheAnimals; Cell Differentiation; Cell Division; Hair; Hair Follicle; Ligands; Mice; Models Biological; Mutation; Stem Cell Niche; Stem Cells; Tamoxifen; Up-Regulation; Wnt Proteins; beta Catenin; Wnt Signaling Pathway; Medicine (all); MultidisciplinaryWnt Signaling Pathwaybeta CateninMultidisciplinaryintegumentary systemAnimalStem CellsMedicine (all)Regeneration (biology)Mesenchymal stem cellWnt signaling pathwayCell DifferentiationHair follicleUp-RegulationCell biologyWnt ProteinsTamoxifenmedicine.anatomical_structureCateninMutationbiology.proteinStem cellHair FollicleCell DivisionHair

description

Coordinated Hair Growth Wnt/β-catenin signaling is a key pathway that plays a conserved role in regulating stem cell function during adult tissue regeneration. Using time-lapse imaging of live mice, Deschene et al. (p. 1353 ) show that genetic activation of β-catenin within hair follicle stem cells generates axes of hair growth by coordinated cell divisions and cell movements, even when the normal niches—the dermal papillae—are laser-ablated. Activated β-catenin enhances Wnt ligand secretion, and these ligands can then activate Wnt signaling in adjacent cells that do not have activated β-catenin, indicating how activated stem cells could influence neighboring cells during normal growth and in cancer.

yearjournalcountryeditionlanguage
2014-01-01Science
https://doi.org/10.1126/science.1248373