Author: Rosy Mallik

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Rosy Mallik

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Towards Waltheriones C and D: Synthesis of the Oxabicyclic Core

2017

A route to the oxabicyclic cores of the HIV cytoprotective quinolone alkaloids, waltheriones C and D, is described. The approach relies on a stereospecific transannular bromoetherification followed by reductive debromination. The route can also be rendered enantioselective via enzymatic reduction of a key intermediate (>99:1 er).

Stereospecificity010405 organic chemistryChemistryStereochemistryOrganic ChemistryEnantioselective synthesisHuman immunodeficiency virus (HIV)medicine010402 general chemistrymedicine.disease_cause01 natural sciencesCombinatorial chemistry0104 chemical sciencesSynlett

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