6533b823fe1ef96bd127ea54
RESEARCH PRODUCT
Towards Waltheriones C and D: Synthesis of the Oxabicyclic Core
Juha H. SiitonenRosy MallikKatja KärkiPetri M. PihkoMari Ella Mäkinensubject
Stereospecificity010405 organic chemistryChemistryStereochemistryOrganic ChemistryEnantioselective synthesisHuman immunodeficiency virus (HIV)medicine010402 general chemistrymedicine.disease_cause01 natural sciencesCombinatorial chemistry0104 chemical sciencesdescription
A route to the oxabicyclic cores of the HIV cytoprotective quinolone alkaloids, waltheriones C and D, is described. The approach relies on a stereospecific transannular bromoetherification followed by reductive debromination. The route can also be rendered enantioselective via enzymatic reduction of a key intermediate (>99:1 er).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-02-24 | Synlett |