0000000000535565

AUTHOR

Nevio Picci

showing 3 related works from this author

Drug release from alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide-based microparticles.

2004

Abstract Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymer has been α , β -poly( N -2-hydroxyethyl)- dl -aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) has been crosslinked in the presence of acrylic acid (AA) or methacrylic acid (MA) at various concentration. The obtained microparticles have been characterized by FT-IR spectrophotometry, particle size distribution analysis and scanning electron microscopy. In order to have information about water affinity of the prepared samples, swelling measurements have been carried out in aqueous media which simulate some bi…

Materials scienceChemical structureBiophysicsDrug Evaluation PreclinicalMolecular ConformationBioengineeringAbsorptionBiomaterialsDiffusionchemistry.chemical_compoundDrug Delivery SystemsSpectrophotometryPolymer chemistrymedicineCopolymerParticle SizeAcrylic acidchemistry.chemical_classificationDrug Carriersmedicine.diagnostic_testWaterHydrogelsPolymerMicrospheresBody FluidschemistryMethacrylic acidPharmaceutical PreparationsMechanics of MaterialsDelayed-Action PreparationsCeramics and CompositesSuspension polymerizationSwellingmedicine.symptomPeptidesNuclear chemistryBiomaterials
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Novel water-swellable beads based on an acryloylated polyaspartamide

2001

Spherical polymeric microparticles have been prepared by a reverse-phase suspension polymerization technique. The starting polymer was α,β-poly (N-2-hydroxyethyl)-dl-aspartamide (PHEA) partially functionalised with glycidylmethacrylate (GMA) in order to introduce reactive vinyl groups in the side chain. The PHEA–GMA copolymer obtained (PHG) was cross-linked in a mixture of water/hexane–carbon tetrachloride in the presence of sorbitan trioleate (Span 85) as surfactant and ammonium persulfate/N,N,N′,N′-tetramethylethylenediamine as initiator system. The reaction was also carried out in the presence of N,N′-dimethylacrylamide as comonomer or N,N′-ethylenebisacrylamide as a cross-linking agent.…

Aqueous solutionPolymers and PlasticsComonomerchemistry.chemical_compoundColloid and Surface ChemistryDifferential scanning calorimetrychemistryChemical engineeringPolymer chemistryMaterials ChemistrymedicineCopolymerSide chainAmmonium persulfateSuspension polymerizationPhysical and Theoretical ChemistrySwellingmedicine.symptomColloid & Polymer Science
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Beads of Acryloylated Polyaminoacidic Matrices Containing 5-Fluorouracil for Drug Delivery

2002

Spherical polymeric microparticles have been prepared by a reverse phase suspension polymerization technique. The starting polymer was alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) was crosslinked in the presence of N,N'-dimethylacrylamide (DMAA) or N,N'-ethylenebisacrylamide (EBA). 5-fluorouracil was incorporated into PHG-DMAA or PHG-EBA beads both during and after the crosslinking process. Swelling studies revealed a high affinity toward aqueous medium, influenced by the presence of 5-fluorouracil. The in vitro release study showed that the release rate depends on the chemical structure of the beads…

Antimetabolites AntineoplasticMaterials scienceChemical structurePharmaceutical Sciencemacromolecular substancesExcipientsDrug Delivery SystemsPhase (matter)Polymer chemistryCopolymermedicineParticle Sizechemistry.chemical_classificationCalorimetry Differential ScanningAqueous mediumdigestive oral and skin physiologytechnology industry and agricultureProteinsHydrogelsGeneral MedicinePolymerHydrogen-Ion ConcentrationMicrospheresMolecular WeightKineticsCross-Linking ReagentsAcrylateschemistryDrug deliveryMicroscopy Electron ScanningIndicators and ReagentsSuspension polymerizationFluorouracilSwellingmedicine.symptomDrug Delivery
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