6533b86dfe1ef96bd12c9778
RESEARCH PRODUCT
Beads of Acryloylated Polyaminoacidic Matrices Containing 5-Fluorouracil for Drug Delivery
Sonia TrombinoNevio PicciRita MuzzalupoGaetano GiammonaGiovanna PitarresiPaola Pierrosubject
Antimetabolites AntineoplasticMaterials scienceChemical structurePharmaceutical Sciencemacromolecular substancesExcipientsDrug Delivery SystemsPhase (matter)Polymer chemistryCopolymermedicineParticle Sizechemistry.chemical_classificationCalorimetry Differential ScanningAqueous mediumdigestive oral and skin physiologytechnology industry and agricultureProteinsHydrogelsGeneral MedicinePolymerHydrogen-Ion ConcentrationMicrospheresMolecular WeightKineticsCross-Linking ReagentsAcrylateschemistryDrug deliveryMicroscopy Electron ScanningIndicators and ReagentsSuspension polymerizationFluorouracilSwellingmedicine.symptomdescription
Spherical polymeric microparticles have been prepared by a reverse phase suspension polymerization technique. The starting polymer was alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) was crosslinked in the presence of N,N'-dimethylacrylamide (DMAA) or N,N'-ethylenebisacrylamide (EBA). 5-fluorouracil was incorporated into PHG-DMAA or PHG-EBA beads both during and after the crosslinking process. Swelling studies revealed a high affinity toward aqueous medium, influenced by the presence of 5-fluorouracil. The in vitro release study showed that the release rate depends on the chemical structure of the beads and the procedure adopted to incorporate 5-fluorouracil into the microparticles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-06-11 | Drug Delivery |