6533b823fe1ef96bd127f53f
RESEARCH PRODUCT
Drug release from alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide-based microparticles.
Francesca IemmaNevio PicciPaola PierroGiovanna PitarresiGaetano GiammonaRita Muzzaluposubject
Materials scienceChemical structureBiophysicsDrug Evaluation PreclinicalMolecular ConformationBioengineeringAbsorptionBiomaterialsDiffusionchemistry.chemical_compoundDrug Delivery SystemsSpectrophotometryPolymer chemistrymedicineCopolymerParticle SizeAcrylic acidchemistry.chemical_classificationDrug Carriersmedicine.diagnostic_testWaterHydrogelsPolymerMicrospheresBody FluidschemistryMethacrylic acidPharmaceutical PreparationsMechanics of MaterialsDelayed-Action PreparationsCeramics and CompositesSuspension polymerizationSwellingmedicine.symptomPeptidesNuclear chemistrydescription
Abstract Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymer has been α , β -poly( N -2-hydroxyethyl)- dl -aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) has been crosslinked in the presence of acrylic acid (AA) or methacrylic acid (MA) at various concentration. The obtained microparticles have been characterized by FT-IR spectrophotometry, particle size distribution analysis and scanning electron microscopy. In order to have information about water affinity of the prepared samples, swelling measurements have been carried out in aqueous media which simulate some biological fluids. The possibility to employ the prepared samples as pH-sensitive microparticles has been investigated by performing in vitro release studies. Experimental data have showed that the release rate from these microparticles depends on the environmental pH and the chemical structure of the drug.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-08-01 | Biomaterials |