0000000000535956

AUTHOR

Timothy M. Pawlik

showing 3 related works from this author

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

2014

Pathologymedicine.medical_specialtyGlobal HealthPractice guidelinesPrimary sclerosing cholangitisCholangiocarcinomamedicineHumansIntrahepatic CholangiocarcinomaIntrahepatic cholangiocarcinomaEvidence-Based MedicineBiliary tract cancerHepatologymedicine.diagnostic_testbusiness.industryGastroenterologyRecurrent Intrahepatic Cholangiocarcinomamedicine.diseaseBile Ducts IntrahepaticDiagnosis and managementBile Duct NeoplasmsPositron emission tomographyPractice Guidelines as TopicbusinessComparative genomic hybridizationContrast-enhanced ultrasoundJournal of Hepatology
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Development and Validation of a New Prognostic System for Patients with Hepatocellular Carcinoma

2016

Background Prognostic assessment in patients with hepatocellular carcinoma (HCC) remains controversial. Using the Italian Liver Cancer (ITA.LI.CA) database as a training set, we sought to develop and validate a new prognostic system for patients with HCC. Methods and Findings Prospective collected databases from Italy (training cohort, n = 3,628; internal validation cohort, n = 1,555) and Taiwan (external validation cohort, n = 2,651) were used to develop the ITA.LI.CA prognostic system. We first defined ITA.LI.CA stages (0, A, B1, B2, B3, C) using only tumor characteristics (largest tumor diameter, number of nodules, intra- and extrahepatic macroscopic vascular invasion, extrahepatic metas…

OncologyMaleTime FactorsDatabases FactualCancer Treatmentlcsh:MedicinePredictive Value of TestPediatricsBiochemistryGeographical locationsNeoplasms Multiple PrimaryDecision Support Technique0302 clinical medicineInterquartile rangeRetrospective StudieMultiple PrimaryRisk FactorsNeoplasmsMedicine and Health SciencesEthnicitiesPublic and Occupational HealthLiver DiseasesLiver NeoplasmsChild HealthGeneral MedicineMiddle AgedPrognosisItalian PeopleTumor BurdenQuartileOncologyCirrhosisItalyLiver Neoplasm030220 oncology & carcinogenesisPredictive value of testsCohortPerspectiveHong Kong030211 gastroenterology & hepatologyFemaleSurvival Analysialpha-FetoproteinsHumanBiotechnologymedicine.medical_specialtyCarcinoma HepatocellularAsiaTime FactorSettore MED/12 - GASTROENTEROLOGIAAged; Carcinoma Hepatocellular; Databases Factual; Decision Support Techniques; Female; Humans; Italy; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Neoplasms Multiple Primary; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; Survival Analysis; Taiwan; Time Factors; Tumor Burden; alpha-Fetoproteins; Biotechnology; Biochemistry; Molecular Biology; Cell BiologyTaiwanReproducibility of ResultGastroenterology and HepatologyCarcinomasRisk AssessmentDecision Support Techniques03 medical and health sciencesDatabasesDiagnostic MedicinePredictive Value of TestsInternal medicineGastrointestinal TumorsmedicineHumansNeoplasm Invasivenessalpha-FetoproteinMolecular BiologySurvival analysisFactualAgedNeoplasm StagingRetrospective StudiesNeoplasm InvasivenePerformance statusbusiness.industryRisk Factorlcsh:RCarcinomaCancers and NeoplasmsReproducibility of ResultsRetrospective cohort studyHepatocellularHepatocellular CarcinomaCell BiologySurvival AnalysisBCLC StageSurgeryPeople and PlacesPopulation Groupingsbusiness
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The concept of therapeutic hierarchy for patients with hepatocellular carcinoma: A multicenter cohort study

2019

Background: The Italian Liver Cancer (ITA.LI.CA) prognostic system for patients with hepatocellular carcinoma (HCC) has recently been proposed and validated. We sought to explore the relationship among the ITA.LI.CA prognostic variables (ie tumour stage, functional score based on performance status and Child-Pugh score, and alpha-fetoprotein), treatment selection and survival outcome in HCC patients. Patients and Methods: We analysed 4,867 consecutive HCC patients undergoing six main treatment strategies (liver transplantation, LT; liver resection, LR; ablation, ABL; intra-arterial therapy, IAT; Sorafenib, SOR; and best supportive care, BSC) and enrolled during 2002-2015 in a multicenter It…

MaleOncologySorafenibmedicine.medical_specialtyPrognostic variableCarcinoma Hepatocellularmedicine.medical_treatmenttreatment selectionLiver transplantationhepatocellular carcinoma; prognostic variable; survival benefit; treatment selection;03 medical and health sciencesprognostic variable0302 clinical medicineInternal medicinemedicineHumanssurvival benefithepatocellular carcinoma; prognostic variable; survival benefit; treatment selectionAgedNeoplasm StagingRetrospective StudiesAged 80 and overHepatologyPerformance statusbusiness.industryLiver NeoplasmsHazard ratiohepatocellular carcinomaMiddle Agedmedicine.diseaseConfidence intervalItaly030220 oncology & carcinogenesisHepatocellular carcinomaFemale030211 gastroenterology & hepatologyLiver cancerbusinessmedicine.drug
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