0000000000538935
AUTHOR
Diego Collado-martín
SDHB Expression in Warthin's Tumour
Abstract Introduction Succinic dehydrogenase subunit B (SDHB) is an enzyme belonging to the mitochondrial complex II. The aim of this study is to analyse SDHB expression in a series of Warthin's tumours, studying its relationship with oncocytic changes, constantly present in this form of tumour. Material and methods In resection tumour specimens from a series of ten Warthin's tumours (all from the parotid gland), immunohistochemical expression of SDHB was analysed using a commercially available monoclonal antibody. Results The Warthin's tumours studied affected 10 men (mean age: 64.2 yrs, range 40–80), all with smoking habits, and 2 with metachronous bilateral involvement. Two patients pres…
Solitary polypoid laryngeal xanthoma.
We report the case of a 51-year-old male smoker with diabetes mellitus and hyperlipidaemia and a long history of human immunodeficiency virus (HIV)/hepatitis C virus (HCV) infection treated with various antiretroviral regimes, who was referred to the otolaryngology department with progressive dysphonia. Fibre-optic laryngoscopy showed a solitary, yellowish-white pedunculated polyp on the anterior third of the left cord, with no other abnormality. Pathological analysis revealed a polypoid laryngeal xanthoma that was immunoreactive against CD68, perilipin, and adipophilin. This unusual laryngeal lesion in the clinical context of our patient suggests a possible role of antiretroviral treatment…
Expresión de SDHB en el tumor de Warthin
Resumen Introduccion El objetivo del presente estudio es analizar la expresion de la succinodeshidrogenasa B (SDHB), enzima perteneciente al complejo mitocondrial II, en el tumor de Warthin analizando su relacion con los cambios oncociticos, un dato morfologico constante en este tipo tumoral. Material y metodos En una serie de 10 tumores de Warthin, todos parotideos, se analizo en los especimenes de reseccion tumoral la expresion de SDHB utilizando un anticuerpo monoclonal comercializado. Resultados Los 10 tumores afectaron a 10 varones (edad media: 64, 2 anos; rango: 40-80) , todos ellos con antecedentes de habito tabaquico, y 2 con afectacion bilateral metacronica. Dos pacientes presentar…