0000000000544684

AUTHOR

Sabina Illi

showing 4 related works from this author

Parental hay fever reinforces IgE to pollen as pre-clinical biomarker of hay fever in childhood

2014

An early IgE response to grass or birch pollen can anticipate seasonal allergic rhinitis to pollen later in life or remain clinically silent.To identify risk factors early in life that allow discriminating pathogenic from non-pathogenic IgE responses and contribute to the development of seasonal allergic rhinitis to grass pollen.The German Multicentre Allergy Study examined a birth cohort born in 1990. A questionnaire was yearly administered and blood samples collected at age 1,2,3,5,6,7,10,13 yr. The definition of the primary outcome grass- and birch-pollen-related seasonal allergic rhinitis (SARg, SARb) was based on nasal symptoms in June/July and April, respectively. Serum IgE antibodies…

MaleAdolescentImmunologyImmunoglobulin Emedicine.disease_causeCohort StudiesClinical biomarkerPhleumChild of Impaired ParentsPredictive Value of TestsGermanyPollenotorhinolaryngologic diseasesmedicineHumansImmunology and AllergyRisk factorChildBetulabiologybusiness.industryRhinitis Allergic Seasonalfood and beveragesAllergensAntigens PlantImmunoglobulin Emedicine.diseasebiology.organism_classificationChild PreschoolPhleumPediatrics Perinatology and Child HealthImmunologybiology.proteinPollenHay feverFemaleAntibodybusinessBiomarkersFollow-Up StudiesNasal symptomsPediatric Allergy and Immunology
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Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) seminar.

2012

Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster a…

AllergyAllergyWORLD-HEALTH-ORGANIZATIONBioinformaticsEpigenesis Genetic0302 clinical medicineRisk FactorsImmunology and AllergyMedicineYoung adultChildEpigenesismedia_commonMechanisms of the Development of Allergy0303 health scienceseducation.field_of_studyphenotypesAllergy; Mechanisms of the Development of Allergy; Seventh Framework Program; phenotypes; IgE; asthmaRUSSIAN KARELIAPhenotype3. Good healthLUNG-FUNCTIONPhenotypeChild PreschoolBRONCHIAL HYPERRESPONSIVENESSIgEBIRTH-COHORTAdolescentASTHMA RESEARCH-PROGRAMSystems biologyImmunologyPopulationOBSTRUCTIVE PULMONARY-DISEASEYoung Adult03 medical and health sciencesDIAGNOSTIC GATEKEEPERSHypersensitivityAnimalsHumansmedia_common.cataloged_instanceEuropean unioneducation030304 developmental biologyCLUSTER-ANALYSISbusiness.industryMechanism (biology)ResearchImmunoglobulin Easthmamedicine.disease030228 respiratory systemSeventh Framework ProgramImmunologybusinessT-REGULATORY-CELLS
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Transient suppression of atopy in early childhood is associated with high vaccination coverage.

2003

Objective. To analyze prevalences of allergic sensitization and atopic disease in relation to vaccination coverage. Methods. A German atopy risk-enhanced birth cohort of 1314 neonates who were born in 1990 in 5 German cities was studied. A total of 943 children participated in the follow-up visit at 5 years of age. Atopic symptoms and diagnoses (derived from structured interviews), total serum immunoglobulin E, and specific immunoglobulin E against 9 common allergens (CAP Radio-Allergo-Sorbent Test Fluoro-Enzyme Immunoassay) were evaluated. Children were grouped into dose percentiles according to cumulative doses of any vaccine given up to 5 years of age (<10%, 0–11 doses; 10%–50%, 1…

Pediatricsmedicine.medical_specialtyPercentileDose-Response Relationship ImmunologicImmunoglobulin EDermatitis AtopicAtopyRadioallergosorbent TestHypersensitivityMedicineHumansEarly childhoodSensitizationAsthmaVaccinesbiologybusiness.industryImmunization ProgramsVaccinationInfant NewbornInfantAtopic dermatitisImmunoglobulin Emedicine.diseaseAsthmamedicine.anatomical_structureVaccination coverageChild PreschoolPediatrics Perinatology and Child Healthbiology.proteinbusinessFollow-Up StudiesPediatrics
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Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever.

2012

Background IgE sensitization against grass pollen is a cause of seasonal allergic rhinitis. Objective We sought to investigate the evolution at the molecular level and the preclinical predictive value of IgE responses against grass pollen. Methods The German Multicentre Allergy Study examined a birth cohort born in 1990. A questionnaire was administered yearly, and blood samples were collected at 1, 2, 3, 5, 6, 7, 10, and 13 years of age. Grass pollen–related seasonal allergic rhinitis (SARg) was diagnosed according to nasal symptoms in June/July. Serum IgE antibodies to Phleum pratense extract and 8 P pratense molecules were tested with immune-enzymatic singleplex and multiplex assays, res…

Molecular complexityMaleImmunologyImmunoglobulin EPhleumCohort StudiesPredictive Value of TestsGrass pollenmedicineImmunology and AllergyHumansProspective StudiesChildTimothy-grassbiologybusiness.industryInfantRhinitis Allergic SeasonalImmunoglobulin Ebiology.organism_classificationmedicine.diseasePredictive valueChild PreschoolPhleumImmunologybiology.proteinHay feverFemaleAntibodybusinessThe Journal of allergy and clinical immunology
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