0000000000555690

AUTHOR

Mitchel S. Berger

showing 2 related works from this author

Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension"

2007

Curtis et al . (Research Articles, 2 March 2007, p. 1243) claimed discovery of a human neuronal migratory stream to the olfactory bulb along a putative lateral ventricular extension. However, high levels of proliferation reported with proliferating cell nuclear antigen were not confirmed using different markers, neuronal chain migration was not demonstrated, and no serial reconstruction shows a true ventricular extension.

MultidisciplinaryNeuroblastCell growthbiology.proteinAnatomyCell movementBiologyCell shapeOlfactory bulbCell biologyProliferating cell nuclear antigenScience
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Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

2003

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day. If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative therapy. Stem cells have been isolated from the human brain, but the identity, organization and function of adult neural stem cells in the human SVZ are unknown. Here we describe a ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro. This astrocytic ribbon has not been observed in other vertebrates s…

AdultBiopsyanimal diseasesSubventricular zoneBiologyCell MovementNeurospheremedicineHumansCells CulturedNeuronsMultidisciplinaryMultipotent Stem CellsNeurogenesisBrainCell DifferentiationAnatomyOlfactory BulbNeural stem cellNeuroepithelial cellNeuropoiesismedicine.anatomical_structurenervous systemAstrocytesAutopsyStem cellNeuroscienceCell DivisionAdult stem cellNature
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