0000000000559804

AUTHOR

Jenny Van Dongen

showing 12 related works from this author

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…

AgingMultifactorial InheritanceBLOODEpigenetic clock05 Environmental SciencesbiomarkkeritGenome-wide association studyQH426-470Epigenesis Genetic/dk/atira/pure/core/keywords/icep0302 clinical medicineBiomarkers of agingGWASBiology (General)AdiposityGenetics11832 Microbiology and virology0303 health sciences318 Medical biotechnologyDNA methylation1184 Genetics developmental biology physiologygenomiikkaDna Methylation ; Epigenetic Clock ; Gwasddc:DNA-metylaatioINSIGHTSC-Reactive ProteinepigenetiikkaDNA methylationMENDELIAN RANDOMIZATION/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingEducational StatusICEPGenetic MarkersPROVIDESSUSCEPTIBILITY LOCIBioinformaticsQH301-705.5GenomicsBiology03 medical and health sciencesNHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumAGESDG 3 - Good Health and Well-beingPlasminogen Activator Inhibitor 1REGRESSIONGeneticsHumansEpigeneticsGeneMETAANALYSIS030304 developmental biologyGenome HumanResearchGenetics of DNA Methylation Consortium06 Biological SciencesLipid MetabolismHuman geneticsGenetic architectureImmunity InnateikääntyminenGenetic LociCpG Islands08 Information and Computing Sciences3111 BiomedicineENRICHMENTepigenetic clock030217 neurology & neurosurgeryBiomarkersGenome-Wide Association StudyGranulocytes
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Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts …

2018

Childhood aggression and its resulting consequences inflict a huge burden on affected children, their relatives, teachers, peers and society as a whole. Aggression during childhood rarely occurs in isolation and is correlated with other symptoms of childhood psychopathology. In this paper, we aim to describe and improve the understanding of the co-occurrence of aggression with other forms of childhood psychopathology. We focus on the co-occurrence of aggression and other childhood behavioural and emotional problems, including other externalising problems, attention problems and anxiety-depression. The data were brought together within the EU-ACTION (Aggression in Children: unravelling gene-…

MaleNetherlands Twin Register (NTR)aggressiivisuusPoison controlCHILDRENCBCLComorbidity3124 Neurology and psychiatryCohort Studies0302 clinical medicine3123 Gynaecology and paediatricsADOLESCENTSCo-occurrenceDevelopmental and Educational PsychologyChild and adolescent psychiatryChild10. No inequalitykomorbiditeettiOUTCOMESATTENTION-DEFICIT/HYPERACTIVITY DISORDERHERITABILITY05 social sciencesBIPOLAR DISORDERGeneral MedicineStrengths and Difficulties Questionnairetunne-elämän häiriötJustice and Strong InstitutionsAggressionPsychiatry and Mental healthConduct disorderDUTCH TWINSChild PreschoolFemalemedicine.symptomPsychology050104 developmental & child psychologyClinical psychologyCHARACTERISTIC CURVE ANALYSISmedicine.medical_specialtySDG 16 - PeaceAdolescent515 PsychologyChild psychopathologyChild Behavior Disorders03 medical and health sciencesMENTAL-DISORDERSInjury prevention/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_medicineHumans0501 psychology and cognitive sciencesAffective SymptomsBehavioural and emotional problemsAggressionSDG 16 - Peace Justice and Strong Institutionslapsuusmedicine.disease/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsChildhoodkäyttäytymishäiriötCONDUCT DISORDERPediatrics Perinatology and Child HealthCo-occurence030217 neurology & neurosurgery
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Additional file 4 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 4. Assessment of genomic inflation and heterogeneity.

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Additional file 3 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 3. Supplementary Figures - Figures S1-S31.

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Additional file 6 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 6. Review history.

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Additional file 5 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 5. Colocalization plots.

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Additional file 1 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 1. Individual cohort descriptions and acknowledgements.

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Additional file 5 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 5. Colocalization plots.

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Additional file 6 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 6. Review history.

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Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

2020

AbstractBiological ageing estimators derived from DNA methylation (DNAm) data are heritable and correlate with morbidity and mortality. Leveraging DNAm and SNP data from >41,000 individuals, we identify 137 genome-wide significant loci (113 novel) from meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We report strong genetic correlations with longevity and lifestyle factors such as smoking, education, and obesity. Significant associations are observed in polygenic risk score analysis and to a lesser extent in Mendelian randomization analyses. This study illuminates the genetic …

African americanGenetics0303 health sciencesdNaMGenome-wide association studyBiologyGenome3. Good health03 medical and health sciences0302 clinical medicineAgeingDNA methylationParental longevityEpigenetics030217 neurology & neurosurgery030304 developmental biology
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Additional file 2 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 2. Supplementary Tables -Tables S1-S31.

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Additional file 2 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Additional file 2. Supplementary Tables -Tables S1-S31.

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