0000000000585982

AUTHOR

Renáta Dóró

showing 3 related works from this author

Identification of a multi-reassortant G12P[9] rotavirus with novel VP1, VP2, VP3 and NSP2 genotypes in a child with acute gastroenteritis.

2015

The G12 rotavirus genotype is globally emerging to cause severe gastroenteritis in children. Common G12 rotaviruses have either a Wa-like or DS-1-like genome constellation, while some G12 strains may have unusual genome composition. In this study, we determined the full-genome sequence of a G12P[9] strain (ME848/12) detected in a child hospitalized with acute gastroenteritis in Italy in 2012. Strain ME848/12 showed a complex genetic constellation (G12-P[9]-I17-R12-C12-M11-A12-N12-T7-E6-H2), likely derived from multiple reassortment events, with the VP1, VP2, VP3 and NSP2 genes being established as novel genotypes R12, C12, M11 and N12, respectively. Gathering sequence data on human and anim…

Microbiology (medical)RotavirusGenotypingSettore MED/07 - Microbiologia E Microbiologia ClinicavirusesReassortmentHuman rotaviruGenome ViralBiologymedicine.disease_causeMicrobiologyGenomeRotavirus InfectionsReassortmentRotavirusGenotypeGeneticsmedicineHumansMolecular BiologyGenotypingGeneEcology Evolution Behavior and SystematicsPhylogenyGeneticsWhole genome sequencingViral Structural ProteinsSequence Analysis RNAStrain (biology)virus diseasesVirologyFull genome sequencingGastroenteritisInterspecies transmissionInfectious DiseasesChild PreschoolG12P[9]Reassortant VirusesInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
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Full-genome sequencing of a Hungarian canine G3P[3] Rotavirus A strain reveals high genetic relatedness with a historic Italian human strain

2015

A canine Rotavirus A strain was identified in the fecal specimen of a young dog during 2012 in Hungary. The strain RVA/Dog-wt/HUN/135/2012/G3P[3] shared complete genotype constellation (G3-P[3]-I3-R3-C3-M3-A15-N2-T3-E3-H6) and high genome sequence similarity (nt, 98.8 %) with a historic human strain, RVA/Human-tc/ITA/PA260-97/1997/G3P[3]. This study provides evidence for the canine origin of the unusual NSP1 genotype, A15, and reinforces the hypothesis of direct interspecies transmission of canine rotaviruses to humans.

RotavirusSettore MED/07 - Microbiologia E Microbiologia ClinicaGenotype constellationMolecular Sequence DataGenome ViralBiologymedicine.disease_causeGenomeRotavirus InfectionsViral ProteinsDogsPhylogenetic analysiGeneticPhylogeneticsZoonosiSequence Homology Nucleic AcidRotavirusSemiconductor sequencingVirologyGenotypeGeneticsmedicineAnimalsHumansDog DiseasesMolecular BiologyPhylogenyGeneticsWhole genome sequencingHungaryNSP1Base SequenceStrain (biology)General MedicineIon semiconductor sequencingVirologyItaly
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Complete genome analysis of contemporary G12P[8] rotaviruses reveals heterogeneity within Wa-like genomic constellation

2016

G12 rotaviruses are globally emergent rotaviruses causing severe childhood gastroenteritis. Little is known about the evolution and diversity of G12P[8] rotaviruses and the possible role that widespread vaccine use, globally, has had on their emergence. In Sicily, Italy, surveillance activity for rotaviruses has been conducted uninterruptedly since 1985, thus representing a unique observatory for the study of human rotaviruses in the pre- and post-vaccine era. G12 rotaviruses were first detected only in 2012 and between 2012 and 2014 they accounted for 8.7% of all rotavirus-associated infections among children, with peaks of 27.8% in 2012/2013 and 21% in 2014. We determined and analyzed the…

Rotavirus0301 basic medicineMicrobiology (medical)Settore MED/07 - Microbiologia E Microbiologia ClinicaSettore MED/17 - Malattie InfettivevirusesRotavirus InfectionsInfectious DiseaseGenome ViralBiologyRotavirus vaccinationmedicine.disease_causeGenomeMicrobiologyRotavirus Infections03 medical and health sciencesfluids and secretionsPhylogenetic analysiGeneticPhylogeneticsRotavirusGenotypeGeneticsmedicineHumansG12Antigens ViralMolecular BiologyPhylogenyEcology Evolution Behavior and SystematicsGeneticsPhylogenetic treevirus diseasesFull length-genomeRotaviruVirologyEcology Evolution Behavior and SystematicVaccination030104 developmental biologyInfectious DiseasesItalyCapsid Proteins
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