6533b839fe1ef96bd12a5cc1

RESEARCH PRODUCT

Full-genome sequencing of a Hungarian canine G3P[3] Rotavirus A strain reveals high genetic relatedness with a historic Italian human strain

Vito MartellaSzilvia MartonSzilvia L. FarkasGiovanni M. GiammancoKrisztián BányaiS. De GraziaRenáta DóróHajnalka PappEszter Mihalov-kovács

subject

RotavirusSettore MED/07 - Microbiologia E Microbiologia ClinicaGenotype constellationMolecular Sequence DataGenome ViralBiologymedicine.disease_causeGenomeRotavirus InfectionsViral ProteinsDogsPhylogenetic analysiGeneticPhylogeneticsZoonosiSequence Homology Nucleic AcidRotavirusSemiconductor sequencingVirologyGenotypeGeneticsmedicineAnimalsHumansDog DiseasesMolecular BiologyPhylogenyGeneticsWhole genome sequencingHungaryNSP1Base SequenceStrain (biology)General MedicineIon semiconductor sequencingVirologyItaly

description

A canine Rotavirus A strain was identified in the fecal specimen of a young dog during 2012 in Hungary. The strain RVA/Dog-wt/HUN/135/2012/G3P[3] shared complete genotype constellation (G3-P[3]-I3-R3-C3-M3-A15-N2-T3-E3-H6) and high genome sequence similarity (nt, 98.8 %) with a historic human strain, RVA/Human-tc/ITA/PA260-97/1997/G3P[3]. This study provides evidence for the canine origin of the unusual NSP1 genotype, A15, and reinforces the hypothesis of direct interspecies transmission of canine rotaviruses to humans.

yearjournalcountryeditionlanguage
2015-01-30
10.1007/s11262-014-1163-8http://hdl.handle.net/10447/131820