Antiproliferative effect of main dietary phytosterols and/or b-cryptoxanthin in human colon cancer Caco-2 cells through cytosolic Ca+2-and oxidative stress-induced apoptosis

Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca++ increase and oxidative stress

7-Ketocholesterol (7-KC)-induced apoptosis of macrophages is considered a key event in the development of human atheromas. In the present study, the effect of indicaxanthin (Ind), a bioactive pigment from cactus pear fruit, on 7-KC-induced apoptosis of human monocyte/macrophage THP-1 cells was investigated. A pathophysiological condition was simulated by using amounts of 7-KC that can be reached in human atheromatous plaque. Ind was assayed within a micromolar concentration range, consistent with its plasma level after dietary supplementation with cactus pear fruit. Pro-apoptotic effects of 7-KC were assessed by cell cycle arrest, exposure of phosphatidylserine at the plasma membrane, varia…

The diet phytochemical Indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis via inhibition of redox unbalance, cytosolic Ca2+ increase and NF-kB activation.

Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptotic activity.

Indicaxanthin from Opuntia Ficus Indica exerts antioxidant and anti-inflammatory effects in an in vitro model of human corneal dysfunction.

Antiinflammatory effects of pistachio nut proanthocyanidins in LPS-stimulated RAW264.7 cells