Distribution patterns of fungi and bacteria in saline soils

Saline soils are environments characterized by uneven temporal and spatial water distribution and localized high concentrations of salts. Spatial distribution patterns of fungi and bacteria in saline soils, and the link between microbial community dynamics and salts accumulation are critical issues throughout the world (Ettema, Wardle 2002). This study was focused on spatial distribution patterns of soil fungi and bacteria in a saline soil located in Piana del Signore (Gela, Italy) where some ecological variables acted as shaping factors in aboveground and belowground communities distribution. Bacterial, archaeal, and fungal communities diversity and distribution in ten soil sites (A horizo…

Applying an operating model for the environmental risk assessment in Italian Sites of Community Importance (SCI) of the European Commission Habitats Directive (92/43/EEC)

The fast development of agro-biotechnologies asks for a harmonized approach in risk analysis of GMO's releases, where "risk analysis" entails the assessment, management and communication of risk. Risk assessment consists in the evaluation of the likelihood that a hazard occurs, associated with the presence of the receptor(s) in the receiving environment, and the determination of their potential degree of exposure to the hazard. The whole process has to be both science based and applied case by case, and it involves a very complicated procedure that needs to be transformed in an operational and standardized tool. Beginning in 2003, an expert group on behalf of the Italian Ministry of the Env…

TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)

ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…

Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581] (Journal of Hepatology (2021) 75(3) (572–581), (S0168827821003342), (10.1016/j.jhep.2021.04.055))

It has come to our attention that the name of one of the authors in our manuscript was incorrectly spelled ‘Jinyoung Byan’; the correct spelling is ‘Jinyoung Byun’ as in the author list above. In addition, the excel files of the supplementary tables were not included during the online publication of our article. These have now been made available online. We apologize for any inconvenience caused.

Primary biliary cholangitis (PBC): The patient journey to diagnosis and through the disease

A natural saline soil as a model for understanding to what extent the concentration of salt affects the distribution of microorganisms

Soils preserve and sustain life. Their health and functioning are crucial for crop production and for the maintenance of major ecosystem services. Human induced salinity is one of the main soil threats that reduces soil fertility and affect crop yields. In recent times, great attention has been paid to the general shortage of arable land and to the increasing demand for ecological restoration of areas affected by salinization processes. Despite the diffuse interest on the effects of salinization on plants’ growth, and all the derived socioeconomic issues, very few studies analyzed the ecology of the microbial species in naturally saline soils and the resilience of biological fertility in th…

Correction: Salinity and Bacterial Diversity: To What Extent Does the Concentration of Salt Affect the Bacterial Community in a Saline Soil?

Three authors were omitted from the author contributions section in the ‘‘contributed to the writing of the manuscript’’ subsection. Please refer to the correct author contributions here: Conceived and designed the experiments: LC GB AB. Performed the experiments: LC GB GLP. Analyzed the data: LC GB FP GLP. Contributed reagents/materials/analysis tools: CD AB GLP. Contributed to the writing of the manuscript: LC FP GB.GLP CD AB

Economic Consequences of Investing in Anti-HCV Antiviral Treatment from the Italian NHS Perspective: A Real-World-Based Analysis of PITER Data

OBJECTIVE:\ud We estimated the cost consequence of Italian National Health System (NHS) investment in direct-acting antiviral (DAA) therapy according to hepatitis C virus (HCV) treatment access policies in Italy.\ud \ud METHODS:\ud A multistate, 20-year time horizon Markov model of HCV liver disease progression was developed. Fibrosis stage, age and genotype distributions were derived from the Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. The treatment efficacy, disease progression probabilities and direct costs in each health state were obtained from the literature. The break-even point in time (BPT) was defined as the period of time required for the cumulativ…

Primary Biliary Cholangitis (PBC): The emotional perception of the disease journey from a patient's perspective