0000000000597873
AUTHOR
E. Jiménez Herrero
showing 2 related works from this author
Metotrexato como tratamiento en el penfigoide ocular cicatricial moderado
2014
Resumen Caso clinico Una mujer de 73 anos se presenta con historia de molestias inespecificas y fotofobia en ambos ojos (AO) de un ano de evolucion. A la exploracion se observa un simblefaron bilateral y acortamiento de fondos de saco. El analisis inmunohistoquimico (IHQ) confirma la presencia de un deposito lineal de Ig G, Ig M y C3 a lo largo de la membrana basal conjuntival. Ante el diagnostico de penfigoide ocular cicatricial (POC) se pauta tratamiento sistemico mediante metotrexato (MTX) subcutaneo. Discusion Consideramos dicho tratamiento una alternativa inmunosupresora inicial muy eficaz en pacientes con inflamacion conjuntival moderada y en casos de rapida progresion.
Methotrexate as a treatment in ocular cicatricial moderate pemphigoid.
2013
Abstract Clinical case A 73 year-old woman presented with a history of non-specific symptoms and photophobia in both eyes of 1 year progression. The examination revealed a bilateral symblepharon and fornix shortening. Immunohistochemical analysis confirmed the presence of linear deposits of IgG, IgM and C3 along the conjunctival basement membrane. With the diagnosis of ocular cicatricial pemphigoid, systemic treatment with subcutaneous methotrexate was prescribed. Discussion We consider such treatment a very effective initial immunosuppressive alternative in patients with moderate conjunctival inflammation and in cases of rapid progression.