Metotrexato como tratamiento en el penfigoide ocular cicatricial moderado

6533b826fe1ef96bd1284545

RESEARCH PRODUCT

Metotrexato como tratamiento en el penfigoide ocular cicatricial moderado

E. España Gregori Manuel Díaz-llopis E. Jiménez Herrero D. Salom A. Hervás Ontiveros

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Resumen Caso clinico Una mujer de 73 anos se presenta con historia de molestias inespecificas y fotofobia en ambos ojos (AO) de un ano de evolucion. A la exploracion se observa un simblefaron bilateral y acortamiento de fondos de saco. El analisis inmunohistoquimico (IHQ) confirma la presencia de un deposito lineal de Ig G, Ig M y C3 a lo largo de la membrana basal conjuntival. Ante el diagnostico de penfigoide ocular cicatricial (POC) se pauta tratamiento sistemico mediante metotrexato (MTX) subcutaneo. Discusion Consideramos dicho tratamiento una alternativa inmunosupresora inicial muy eficaz en pacientes con inflamacion conjuntival moderada y en casos de rapida progresion.

year	journal	country	edition	language
2014-11-01	Archivos de la Sociedad Española de Oftalmología

https://doi.org/10.1016/j.oftal.2013.10.009

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