0000000000605889

AUTHOR

Beate Wollinsky

showing 2 related works from this author

Isolactarane and Sterpurane Sesquiterpenoids from the Basidiomycete Phlebia uda

2012

Three new sesquiterpenoids, named udasterpurenol A, udalactarane A, and udalactarane B, as well as the known compounds hyphodontal and sterpuric acid have been isolated from the basidiomycete Phlebia uda. These compounds represent the first natural products described from this species. The structures were elucidated by NMR spectroscopy and mass spectrometry. Udalactaranes A and B were isolated as mixtures with their respective epimeric acetals. These mixtures inhibited the spore germination of the plant pathogenic fungus Fusarium graminearum at 10 and 5 μg/mL, respectively, and were active against Jurkat cells with IC(50) values of 101 and 42 μM, respectively.

FusariumStereochemistryPharmaceutical ScienceMicrobial Sensitivity TestsMass spectrometryAnalytical ChemistryInhibitory Concentration 50Jurkat CellsFusariumDrug DiscoveryIc50 valuesSpore germinationHumansNuclear Magnetic Resonance BiomolecularPharmacologyMolecular StructurebiologyBasidiomycotaOrganic ChemistryBasidiomycotaNuclear magnetic resonance spectroscopyPathogenic fungusbiology.organism_classificationPhlebia udaComplementary and alternative medicineMolecular MedicineSesquiterpenesJournal of Natural Products
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Hirsutane-Type Sesquiterpenes with Uncommon Modifications from Three Basidiomycetes

2010

From three basidiomycetes, Xeromphalina sp., Stereum sp., and Pleurocybella porrigens, six triquinane sesquiterpenes with unprecendented modifications and a rearranged sesquiterpene related to coriolin C have been isolated. Their isolation, structure elucidation, and biological evaluation are described.

Bridged-Ring CompoundsPolycyclic SesquiterpenesAntifungal AgentsBacteriaMolecular StructurebiologyStereochemistryXeromphalinaBasidiomycotaOrganic ChemistryFungibiology.organism_classificationSesquiterpenePleurocybella porrigensTerpenoidAnti-Bacterial Agentschemistry.chemical_compoundchemistryOrganic chemistryStereumSesquiterpenesBiological evaluationThe Journal of Organic Chemistry
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