6533b826fe1ef96bd1285203

RESEARCH PRODUCT

Isolactarane and Sterpurane Sesquiterpenoids from the Basidiomycete Phlebia uda

Anja SchüfflerJohannes C. LiermannBeate WollinskyTimm AnkeTill Opatz

subject

FusariumStereochemistryPharmaceutical ScienceMicrobial Sensitivity TestsMass spectrometryAnalytical ChemistryInhibitory Concentration 50Jurkat CellsFusariumDrug DiscoveryIc50 valuesSpore germinationHumansNuclear Magnetic Resonance BiomolecularPharmacologyMolecular StructurebiologyBasidiomycotaOrganic ChemistryBasidiomycotaNuclear magnetic resonance spectroscopyPathogenic fungusbiology.organism_classificationPhlebia udaComplementary and alternative medicineMolecular MedicineSesquiterpenes

description

Three new sesquiterpenoids, named udasterpurenol A, udalactarane A, and udalactarane B, as well as the known compounds hyphodontal and sterpuric acid have been isolated from the basidiomycete Phlebia uda. These compounds represent the first natural products described from this species. The structures were elucidated by NMR spectroscopy and mass spectrometry. Udalactaranes A and B were isolated as mixtures with their respective epimeric acetals. These mixtures inhibited the spore germination of the plant pathogenic fungus Fusarium graminearum at 10 and 5 μg/mL, respectively, and were active against Jurkat cells with IC(50) values of 101 and 42 μM, respectively.

yearjournalcountryeditionlanguage
2012-06-29Journal of Natural Products
https://doi.org/10.1021/np3000552