0000000000606489

AUTHOR

Giuseppe Colella

showing 34 related works from this author

Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection

2004

Proliferative verrucous leukoplakia (PVL) is a very aggressive form of oral leukoplakia (OL) with high morbidity and mortality rates, hypothesised to be linked to HPV infection. This study aimed to determine the presence of HPV DNA in PVL in comparison with OL, and in relation to social-demographical variables (age, gender, smoking and drinking habits) in an Italian multi-centric hospital-based study. The study group consisted of 58 cases of PVL and 90 cases of OL as controls (47 homogeneous (H) and 43 non-homogeneous (non-H) form), both recruited from four Italian cohorts. HPV DNA was identified in exfoliated mucosal cells by nested PCR (nPCR) with MY09/MY11 and GP5+/GP6+ primer pairs and …

AdultOralMaleCancer Researchmedicine.medical_specialtyGenotypeGastroenterologyVirusVerrucousRisk FactorsInternal medicineGenotypemedicineCarcinomaHumansCarcinoma VerrucousViralPapillomaviridaeRisk factorPapillomaviridaeLeukoplakiaAdult; Carcinoma; Verrucous; DNA; Viral; Female; Genotype; Humans; Leukoplakia; Oral; Male; Middle Aged; Papillomaviridae; Papillomavirus Infections; Risk Factors; SmokingbiologyCarcinomaPapillomavirus InfectionsSmokingHPV infectionvirus diseasesDNAMiddle Agedmedicine.diseasebiology.organism_classificationVirologyfemale genital diseases and pregnancy complicationsOncologyDNA ViralFemaleOral SurgeryLeukoplakia OralNested polymerase chain reactionLeukoplakia
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TLR4 down-regulation identifies high risk HPV infection and integration in head and neck squamous cell carcinomas

2015

TLRs are main actors of the innate immune response against HPV. There are very few studies on the role of TLRs mediated HPV clearance in Head and Neck oncology. Our aim was to evaluate whether TLR4 expression identifies HPV infection and/or HR-HPV integration status in oral and oropharyngeal cancers. By immunohistochemistry we assessed TLR4 levels in OSCC/OPSCC. To detect viral integration or episomic status In situ hybridization for HPV-DNA and Pyro-sequencing techniques have been performed. The relationship between TLR4 expression with HPV infection status has been investigated. ISH HPV positive samples have reported lower levels of TLR4 intensity than negative samples (p = .002). There w…

Oncology0301 basic medicineAdultMalemedicine.medical_specialtyVirus IntegrationCellDown-RegulationIn situ hybridizationBiologyAlphapapillomavirusGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesRetrospective StudieInternal medicineCarcinomamedicineHumansVirus IntegrationIn Situ HybridizationRetrospective StudiesAgedAged 80 and overInnate immune systemGeneral Immunology and MicrobiologyHead and Neck NeoplasmAlphapapillomaviruExpression indexHPV infectionvirus diseasesMiddle Agedmedicine.diseasefemale genital diseases and pregnancy complicationsToll-Like Receptor 4medicine.anatomical_structure030104 developmental biologyHead and Neck NeoplasmsImmunologyDNA ViralCarcinoma Squamous CellImmunohistochemistryFemaleHuman
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HPV infection in relation to OSCC histological grading and TNM stage. Evalutation by traditional statistics and fuzzy logic model

2006

We aimed to evaluate if in oral squamous cell carcinoma (OSCC) there is a relationship between histological grading (HG), TNM clinical stage and HPV infection; and to study the performance of fuzzy logic compared to traditional statistics, in the analysis of HPV status and correlates of OSCC. In cross-sectional analysis, the study group comprised 63 patients (mean age 68.89 years (SD ± 11.78), range (32–93); males 28 (44.4%), females 35 (55.6%)) with OSCC histologically diagnosed. HPV-DNA was studied in exfoliated oral epithelial cells by nested PCR (MY09/MY11 and GP5+/GP6+ primers). Data were analysed in parallel by traditional statistics with multivariate analysis and a fuzzy logic (FL) t…

AdultMaleCancer ResearchMultivariate analysisStage iiBiologyModels BiologicalFuzzy LogicStatisticsCarcinomamedicineHumansGrading (tumors)AgedAged 80 and overOSCC HPV-DNA GradingPapillomavirus InfectionsHPV infectionMiddle Agedmedicine.diseasestomatognathic diseasesCross-Sectional StudiesIncreased riskOncologyMultivariate AnalysisCarcinoma Squamous CellFemaleMouth NeoplasmsPrimary tumour sizeOral SurgeryStage iv
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Diagnostic delay in oral squamous cell carcinoma: the role of cognitive and psychological variables

2014

This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma (OSCC), the variables related to diagnostic delay ascribable to the patient, with particular reference to the cognitive and psychological ones. A total of 156 patients with OSCC (mean age: 62 years, M/F: 2.39∶1) were recruited at the Universities of Palermo and Naples. Risk factors related to patient delay included: sociodemographic, health-related, cognitive and psychological variables. The analysis was conducted by considering two different delay ranges: dichotomous (≤1 month vs. >1 month) and polytomous (3 months) delay. Data were investigated…

AdultMaleHealth Knowledge Attitudes Practicemedicine.medical_specialtyPathologyDelayed DiagnosisMultivariate analysisdiagnosisHealth BehaviorPopulationDenial PsychologicalCohort StudiesCognitionSettore MED/28 - Malattie OdontostomatologicheInternal medicinemedicineHumanseducationGeneral DentistryAgedRetrospective StudiesAged 80 and overMouth neoplasmeducation.field_of_studybusiness.industryAge FactorsPolytomous Rasch modelRetrospective cohort studyFearOdds ratioAwarenessMiddle AgedConfidence intervaldiagnosiSocioeconomic FactorsOral squamous cell carcinomaCarcinoma Squamous CellOriginal ArticleFemaleMouth Neoplasmscognitive/psychological factorsbusinessAttitude to Healthpatient delayCohort studyInternational Journal of Oral Science
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Expression of salivary biomarkers in patients with oral mucositis: evaluation by SELDI-TOF/MS.

2016

Objective: This study aims to evaluate changes in proteomic salivary profile of patients with oral mucositis after adjuvant cancer treatments. Materials and Methods: Samples were collected from patients after adjuvant cancer therapies, and were analyzed by means of SELDI/TOF. Patients were separated in two groups: patients affected by mucositis (MUCOSITIS) and patient without mucositis (NO MUCOSITIS). All patients were divided in function of the anticancer treatment: patients who had radiotherapy (MUCOSITIS RADIO), had not radiotherapy (MUCOSITIS NO RADIO), had chemotherapy (MUCOSITIS CHEMO), and those who had not chemotherapy (MUCOSITIS NO CHEMO). Statistical evaluation PCA (Principal Comp…

0301 basic medicineAdultMalemedicine.medical_specialtySalivaPathologymedicine.medical_treatmentGastroenterologySELDI-TOF/MS; biomarker discovery; oral mucositis; saliva; Adult; Aged; Aged 80 and over; Biomarkers; Chemotherapy Adjuvant; Female; Humans; Male; Middle Aged; Neoplasms; Radiation Injuries; Radiotherapy Adjuvant; Saliva; Stomatitis; Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization03 medical and health sciences0302 clinical medicineInternal medicineNeoplasmsbiomarker discoverymedicineMucositisHumansRadiation InjurieRadiation InjuriesSalivaGeneral DentistryStomatitisAgedAged 80 and overChemotherapyStomatitisbusiness.industryCancerSELDI-TOF/MSBiomarkerMiddle Agedmedicine.diseaseStomatitiRadiation therapy030104 developmental biologyOtorhinolaryngologyChemotherapy Adjuvant030220 oncology & carcinogenesisSpectrometry Mass Matrix-Assisted Laser Desorption-IonizationBiomarker (medicine)NeoplasmFemaleRadiotherapy AdjuvantbusinessAdjuvantoral mucositiBiomarkersHumanOral diseases
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Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

Part iiimedicine.medical_specialtyRound tablebusiness.industryPhysiologyGeneral surgeryPhysiology (medical)Oral and maxillofacial pathologymedicineItalian Consensus Medication-Related OsteoNecrosis of Jaws MRONJmedicine.diseasebusiness
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Oral self-injuries: clinical findings in a series of 19 patients

2015

Objectives: Self-injury (SI) is defined as a behavioral disturbance consisting of a deliberate harm to one’s own body without suicidal intent, it is not uncommon and ranges in severity from simple nail-biting to more extreme forms of self-mutilation. The head neck region may be the target of such lesions. SI is associated with several medical conditions, of which it can represent the first clinical sign. Aim of this paper is to describe a series of oral SI, giving special emphasis to the clinical findings, etiology and the management of lesions. Material and Methods: A total of 19 patients with oral SI were prospectively examined; attention was paid to the occurrence and characterization of…

AdultMalemedicine.medical_specialtyPediatricsAdolescentPoison controlOdontologíaDiseaseLesionYoung AdultInjury preventionmedicineHumansMedical historyAdolescent; Adult; Aged; Aged 80 and over; Child; Female; Humans; Male; Middle Aged; Mouth; Prospective Studies; Wounds and Injuries; Young Adult; Self-Injurious BehaviorProspective StudiesYoung adultProspective cohort studyChildGeneral DentistryAgedAged 80 and overMouthOral Medicine and Pathologybusiness.industryResearchWounds and InjurieMiddle Aged:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludSurgeryProspective StudieOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASEtiologyWounds and InjuriesSurgeryFemalemedicine.symptombusinessSelf-Injurious BehaviorHuman
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Effects of p63 expression on survival in oral squamous cell carcinoma

2007

BACKGROUND: P63 is the protein codified by p63 gene, a p53 gene homolog, known for its pivotal role in cell cycle regulation, and involved in the tumor differentiation. Aims of the present study were to assess the frequency and pattern of p63 protein expression in oral squamous cell carcinoma (OSCC) in relation to the main tumour characteristics and to verify whether p63 can be considered a marker of prognosis in patients with OSCC. MATERIAL AND METHODS: In a retrospective study, a cohort of 64 OSCC patients was investigated for p63 protein expression and its cellular localization by immunohistochemistry (monoclonal mouse anti-human p63 protein-clone 4A4). After grouping by p63 expression, …

OncologyAdultMaleCancer Researchmedicine.medical_specialtyPathologySurvival rateBiologyOSCCInternal medicinemedicineBiomarkers TumorCox regression analysisHumansGrading (tumors)GeneSurvival rateCellular localizationAgedNeoplasm StagingCox regression analysis; OSCC; p53 family; p63; Survival rate;p63integumentary systemTumor Suppressor ProteinsRetrospective cohort studyGeneral MedicineMiddle AgedPrognosisSurvival Analysisp63 p53 family OSCC Survival rate Cox regression analysisDNA-Binding Proteinsstomatognathic diseasesOncologyCohortMonoclonalCarcinoma Squamous CellTrans-ActivatorsImmunohistochemistryFemaleMouth NeoplasmsOSCCsense organsp53 familyp53 familyCox regressionTranscription Factors
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Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Ora…

2021

Background: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results: Oral lichen planus pati…

OralSleep Wake DisordersCancer Researchmedicine.medical_specialtyanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbance; Anxiety; Case-Control Studies; Depression; Female; Humans; Pathology Oral; Reproducibility of Results; Sleep; Surveys and Questionnaires; Lichen Planus Oral; Sleep Wake DisordersinsomniaReproducibility of Resultoral lichen planuPathology and Forensic MedicineSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHEPittsburgh Sleep Quality Indexoral lichen planusstomatognathic systemSurveys and QuestionnairesInsomniamedicineNumeric Rating ScalePathologySurveys and QuestionnaireHumansanxiety; insomnia; mood disturbance; oral lichen planus; sleep disturbancemood disturbanceSleep disorderbusiness.industryDepressionEpworth Sleepiness ScaleLichen PlanusReproducibility of ResultsRating scales for depressionmedicine.diseaseanxietysleep disturbancehumanitiesstomatognathic diseasesOtorhinolaryngologyCase-Control StudiesPathology OralPhysical therapyPeriodonticsAnxietyOral lichen planusFemaleOral Surgerymedicine.symptomCase-Control StudiebusinessSleepHumanLichen Planus Oral
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Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

On 20 October 2018 a Closed Round Table brought together a wide range of stakeholders from several medical disciplines, including academic experts, dentists, oncologists, maxillo-facial surgeons, oral surgeons, radiologists, under the technical and scientific coordination of Giuseppina Campisi (for SIPMO) and Giacomo Oteri (for Italian Society of Oral Surgery- SIdCO).

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchinePhysiologySettore MED/28 - Malattie OdontostomatologichePhysiology (medical)italian consensus mroj
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P254 Survivin detection in saliva samples from patients with oral squamous cell carcinoma

2007

Salivabusiness.industrySurvivinCancer researchMedicineBasal cellbusinessOral Oncology Supplement
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Expression of sexual hormones receptors in oral squamous cell carcinoma.

2011

Sexual hormones play an important role in expression of genes involved in a wide variety of biological and neoplastic processes. The information on Estrogen Receptors (ER) expression in non-target tissues is very few and, in particular, the studies in head and neck tumors are still controversial. Recent studies analyzed the role of Tamoxifen (TAM) on Oral Squamous Cell Carcinoma (OSCC) lines in relation to the presence/absence of ER. The purpose of the present study was to evaluate the expression of sexual hormones receptors mRNAs, in particular Estrogen Receptor alpha (ERα) and Androgen Receptor (AR) mRNA in OSCC tissues. The study group comprised 20 samples of OSCC, harvested from 20 oth…

OncologyAdultMalemedicine.medical_specialtyImmunologyEstrogen receptorBiologyOral Squamous Cell CarcinomaSettore MED/28 - Malattie OdontostomatologicheEstrogen ReceptorsInternal medicinemedicineCarcinomaImmunology and AllergyHumansAndrogen Receptors; Estrogen Receptors; Oral Squamous Cell Carcinoma;Oral mucosaReceptorAgedPharmacologyOral squamous cell carcinoma estrogen receptorsAndrogen receptorEstrogen Receptor alphaCancerMiddle Agedmedicine.diseaseAndrogen receptormedicine.anatomical_structureReceptors AndrogenCase-Control StudiesCancer researchCarcinoma Squamous CellFemaleMouth NeoplasmsEstrogen receptor alphaTamoxifenmedicine.drugSexual hormones OSCCAndrogen Receptors
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Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retro…

2012

Abstract PURPOSE: The aim of this study was to evaluate the results of the surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a large cohort. MATERIALS AND METHODS: A retrospective cohort multicenter study was designed. Patients were enrolled if they were diagnosed with BRONJ and received operative treatment. Data on demographic, health status, perioperative, and surgical factors were collected retrospectively. The primary outcome variable was a change in BRONJ staging (improvement, worsening, or no change). Interventions were grouped by local debridement and resective surgery. Data were collected for other variables as cofactors. Univariate analysis and logist…

AdultMalemedicine.medical_specialtyMultivariate analysismedicine.medical_treatmentLogistic regressionSettore MED/28 - Malattie OdontostomatologicheHumansMedicinebisphosphonate-related osteonecrosis of the jawsAgedRetrospective StudiesAnalysis of VarianceUnivariate analysisChi-Square Distributionbusiness.industryRetrospective cohort studyPerioperativeMiddle AgedBisphosphonatemedicine.diseaseOsteotomySurgeryTreatment OutcomeDebridementItalyOtorhinolaryngologySurgical Procedures OperativeTooth ExtractionRegression AnalysisBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgeryOral SurgerybusinessOsteonecrosis of the jawChi-squared distribution
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Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

2020

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SI…

bisphosphonateOral SurgeonHealth Toxicology and Mutagenesislcsh:MedicineMRONJantiangiogenic agents; antiresorptive drugs; bisphosphonates; cancer; denosumab; dentistry; MRONJ; oral surgery; osteoporosis; prevention models; bisphosphonate-associated osteonecrosis of the jaw; bone density conservation agents; diphosphonates; humans; Italy; quality of life0302 clinical medicineprevention modelCancerantiangiogenic agentsdentistryBone Density Conservation AgentsDiphosphonatesConference ReportBisphosphonatesAntiresorptive DrugsDenosumabItaly030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawDenosumabmedicine.drugoral surgerymedicine.medical_specialtyOral surgery03 medical and health sciencesOral surgeryAntiangiogenic agentsOral and maxillofacial pathologymedicinecancerHumansantiangiogenic agentantiresorptive drugsIntensive care medicinePrevention modelsbisphosphonatesantiresorptive drugAntiangiogenic agentsbusiness.industrylcsh:RPublic Health Environmental and Occupational Healthdenosumab030206 dentistrymedicine.diseaseosteoporosisAntiresorptive drugsDentistryOsteoporosisprevention modelsbusinessAntiangiogenic agents; Antiresorptive drugs; Bisphosphonates; Cancer; Denosumab; Dentistry; MRONJ; Oral surgery; Osteoporosis; Prevention models
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TLR4 expression in ex-Lichenoid lesions—oral squamous cell carcinomas and its surrounding epithelium: the role of tumor inflammatory microenvironment

2022

Toll-like receptors (TLRs) regulate innate and adaptive immune responses. Moreover, TLRs can induce a pro-survival and pro-proliferation response in tumor cells. This study aims to investigate the expression of TLR4 in the epithelium surrounding oral squamous cell carcinomas (OSCC) in relation to its inflammatory microenvironment. This study included 150 human samples: 30 normal oral control (NOC), 38 non-lichenoid epithelium surrounding OSCC (NLE-OSCC), 28 lichenoid epithelium surrounding OSCC (LE-OSCC), 30 OSCC ex-non oral lichenoid lesion (OSCC Ex-NOLL), and 24 OSCC ex-oral lichenoid lesion (OSCC Ex-OLL). TLR4 expression was investigated by immunohistochemistry and the percentage of posi…

InflammationSquamous Cell Carcinoma of Head and NeckNeoplasias bucaisBiochemistryReceptor 4 toll-likeEpitheliumToll-like receptorsToll-Like Receptor 4stomatognathic diseasestoll-like receptorsTumor microenvironmentinflammationMicroambiente tumoralHumanstoll-like receptortumor microenvironmentMouth Neoplasmshead and neck cancerTLR4Carcinoma de células escamosas de cabeça e pescoçohead and neck cancer; tumor microenvironment; inflammation; toll-like receptors; TLR4Head and neck cancerMolecular Biology
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“Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection” [Oral Oncology 40 (2004) 835–840]

2005

a Department of Oral Sciences, University of Palermo, Via del Vespro 129, Palermo 90127, Italy b Department of Microbiology, University of Palermo, Via del Vespro 133, Palermo 90127, Italy c Department of Head and Neck Pathology, II University of Napoli Piazza Miraglia, 80100, Italy d Department of Biomedical sciences and Human Oncology, Section of Oral Medicine, School of Medicine and Dentistry, University of Turin, Corso Dogliotti, 14, Torino 10126, Italy e Department of Dentistry and Surgery, Pizza G. Cesare 11, Bari 70124, Italy

Cancer ResearchPathologymedicine.medical_specialtybusiness.industryGeneral surgeryHPV infectionmedicine.diseaseIncreased riskOncologyMedicineOral SurgerybusinessOral oncologyHead and neckOral medicineLeukoplakiaOral Oncology
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Psychological profile and unexpected pain in oral lichen planus: a case-control multicenter SIPMO study

2021

Objectives: To analyze psychological profiles, pain and oral symptoms in patients with oral lichen planus (OLP). Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes) and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered. Results: Th…

medicine.medical_specialtyoral lichen planuPittsburgh Sleep Quality IndexSettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE03 medical and health sciences0302 clinical medicineoral lichen planusstomatognathic systemmental disordersmedicineanxiety; depression; oral lichen planus; pain; sleep disturbancepainGeneral DentistrySleep disorderbusiness.industryEpworth Sleepiness ScaleRating scales for depression030206 dentistrymedicine.diseaseanxietysleep disturbanceDermatologyhumanitiesstomatognathic diseasesPeripheral neuropathyOtorhinolaryngologyMood disorders030220 oncology & carcinogenesisdepressionAnxietyOral lichen planusmedicine.symptombusiness
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Osteonecrosis of the jaw (ONJ) risk in breast cancer patients after zoledronic acid treatment

2010

The importance of adoption of recommendations for ONJ prevention strategy will notably grow for zoledronic acid in the next future, in view of possible further enlargement of its indications (even with different timing and schedules) in breast cancer patients without bone metastases (such as in adjuvant and neo-adjuvant settings, and in hormonotherapy-induced osteopenia

Oncologymedicine.medical_specialtyBreast Neoplasmszoledronic acidBreast cancerSettore MED/28 - Malattie OdontostomatologicheInternal medicinemedicineHumansBone Density Conservation AgentsDiphosphonatesOsteonecrosis of the jawbusiness.industryImidazolesOsteonecrosisGeneral Medicinemedicine.diseaseosteonecrosis jawsZoledronic acidJawbreast cancer patientsFemaleSurgerybusinessOsteonecrosis of the jawmedicine.drugThe Breast
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Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence-a multi-centre study

2011

Abstract Introduction Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date, research has primarily focused on the development and progression of BRONJ in cancer patients with bone metastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arise from a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy. Patients and methods This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008 at eleven different European clinical centres and has resulted in the …

medicine.medical_specialtyTime FactorsSettore MED/09 - Medicina Internamedicine.medical_treatmentOral Surgical ProceduresOsteoporosisAdministration OralSettore MED/28 - Malattie OdontostomatologicheInternal medicinemedicineHumansMedical historyAdverse effectBone Density Conservation AgentsDiphosphonatesDose-Response Relationship Drugbusiness.industryContraindicationsOsteonecrosisBisphosphonatemedicine.diseaseSurgeryZoledronic acidOtorhinolaryngologyCohortOral and maxillofacial surgeryOsteoporosisSurgeryOral Surgeryosteoporosis bisphosphonates ostenecrosis jawsOsteonecrosis of the jawbusinessJaw Diseasesmedicine.drug
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American Association of Oral and Maxillofacial Surgeons position paper: Bisphosphonate-Related Osteonecrosis of the Jaws-2009 update: the need to ref…

2009

With reference to the 2009 update of the American Association of Oral and Maxillofacial Surgeons posi- tion paper, Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ), a relevant modification to the previous classification has been made and a new stage (0) added. The latter stage has been defined as “patients with no clinical evidence of necrotic bone, but who present with nonspecific symptoms or clinical and radiographic findings . . .” and the need for various clinical and radiologic aspects in defining this condi- tion was confirmed. .

medicine.medical_specialtyMaxillofacial surgeonsbusiness.industryGeneral surgerymedicine.medical_treatmentAssociation (object-oriented programming)MEDLINEBisphosphonateOtorhinolaryngologySettore MED/28 - Malattie OdontostomatologichePosition paperMedicineSurgeryOral SurgerybusinessBisphosphonates Osteonecrosis Jaws
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H3 and H3.3 histone mRNA amounts and ratio in oral squamous cell carcinoma and leukoplakia.

2006

Histone variants (e.g. H3) play an important role in chromatin structure and gene expression regulation of normal cells. Aims of this study were to: (1) estimate H3 and H3.3 histone mRNA expressions and their ratio in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OL); (2) investigate whether H3 and H3.3 variants could play a role in the pathogenesis of OSCC and OL, also conditionally to HPV infection, age, gender, and main habits (tobacco smoking and alcohol drinking) in human beings studied. Twenty-three cases of OSCC and 20 cases of OL were examined in lesion site (LS) and juxtaposed clinically undamaged site (JUS) by RT-PCR for H3 and H3.3 histone mRNA; 13 healthy oral mucosa…

MaleHPVH3.3 histone mRNAAlcohol Drinking"carcinoma"BiologyH3 histone mRNAoral leukoplakiaPathogenesisHistonesleucoplakia"Sex FactorsRisk FactorsmedicineCarcinomaHumansRNA MessengerOral mucosaGeneral DentistryPapillomaviridaeLeukoplakiaAgedRegulation of gene expressionMessenger RNAPapillomavirus InfectionsSmoking"H3 histones"HPV infectionAge FactorsMouth MucosaMiddle Agedmedicine.diseaseMolecular biologyoral squamous cell carcinomastomatognathic diseasesmedicine.anatomical_structureHistoneOtorhinolaryngologyDNA Viralbiology.proteinCarcinoma Squamous CellFemaleMouth NeoplasmsLeukoplakia OralOral diseases
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Effect of c-Met expression on survival in head and neck squamous cell carcinoma

2005

The proto-oncogene c-Met has been suggested to be associated with progression of squamous cell carcinoma of the head and neck. The aims of the present study were to assess the prevalence of c-Met expression in oral squamous cell carcinoma (OSCC) and to verify whether c-Met can be considered a marker of prognosis in these patients. In a retrospective study, a cohort of 84 OSCC patients was investigated for c-Met expression and its cellular localization by immunohistochemistry. After grouping for c-Met expression, OSCC patients were statistically analyzed for the variables age, gender, histological grading, tumor node metastasis, staging and overall survival rate. Univariate and multivariate …

OncologyAdultMalemedicine.medical_specialtyc-Met; Cox regression analysis; Oral squamous cell carcinoma;C-MetAdolescentcox regression analysisProto-Oncogene Maschemistry.chemical_compoundInternal medicinemedicineBiomarkers TumorHumansBasal cellHead and neckc-MetNeoplasm Stagingbusiness.industryMouth MucosaGeneral MedicineMiddle AgedProto-Oncogene Proteins c-metmedicine.diseasePrognosisHead and neck squamous-cell carcinomaImmunohistochemistryUp-Regulationoral squamous cell carcinomastomatognathic diseaseschemistryCarcinoma Squamous CellFemaleMouth Neoplasmsbusiness
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Surgery-triggered and non surgery-triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): A retrospective analysis of 567 cases in an Ita…

2011

Invasive local procedures are often reported in clinical history of patients suffering from Bisphosphonates-Related Osteonecrosis of the Jaws (BRONJ) but over 40% of spontaneous forms have been also described in literature. We compared age, gender, underlying bone disorders, bisphosphonate therapy, clinical features and surgical outcome of 205 cases (36.2%) of BRONJ non surgery-triggered (group 1) with 362 (63.8%) cases of surgery-triggered forms (group 2). Differences between group 1 and 2 were analysed using Mann-Whitney U and χ2 tests. Statistical analysis was performed using STATA 8. Zoledronate was the most used type of bisphosphonate (63.4% versus 69.0%) and the mandible was the most …

AdultMaleCancer Researchmedicine.medical_specialtyTooth extractionmedicine.medical_treatmentZoledronic AcidSettore MED/28 - Malattie OdontostomatologicheRisk FactorsClinical historySpontaneous formmedicineRetrospective analysisHumansStatistical analysisStage (cooking)AgedRetrospective StudiesAged 80 and overSurgical outcomeBone Density Conservation AgentsDiphosphonatesBRONJOrthognathic Surgical Proceduresbusiness.industryImidazolesOsteonecrosisBisphosphonates-related Osteonecrosis of the JawMiddle AgedBisphosphonateSurgeryZoledronic acidItalyOncologyMulticenter studyFemaleBisphosphonate therapyOral SurgerybusinessJaw Diseasesmedicine.drugOral Oncology
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Clinical Validation of 13-gene DNA Methylation Analysis from Oral Brushing: A Non Invasive Sampling Procedure for Early Detection of Oral Squamous Ce…

2019

In a recent study our research group described a non-invasive sampling procedure based on [...]

Oncologymedicine.medical_specialtyoral brushing;oral squamous cell carcinoma; quantitative DNA methylation analysisbusiness.industryEarly detectionSampling (statistics)oral brushingoral squamous cell carcinomaInternal medicineDNA methylationMedicinequantitative DNA methylation analysisBasal cellGene DNA Methylation Analysis Oral Brushing Non Invasive Sampling Early Detection Oral Squamous Cell CarcinomabusinessNon invasive samplingGeneThe XV National and III International Congress of the Italian Society of Oral Pathology and Medicine
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Efficacy of a Spray Compound Containing a Pool of Collagen Precursor Synthetic Amino Acids (L-Proline, L-Leucine, L-Lysine and Glycine) Combined with…

2010

Oral mucositis (OM) is a very frequent and potentially severe complication experienced by patients receiving chemotherapy and/or radiotherapy, which often leads to significant morbidity and mortality, and decreased quality of life, and is very costly. Despite its severity and prevalence, there is no standard recognised management today. The aim of this open clinical trial is to evaluate the efficacy and compliance of a new spray compound containing sodium hyaluronate (SH) and a pool of collagen precursor amino acids (AAs) combined with sodium hyaluronate (SH) to manage radio/chemotherapy-induced OM. Twenty-seven consecutive patients with OM were treated according to the manufacturer's inst…

AdultMalemedicine.medical_specialtyAdolescentProlineVisual analogue scalemedicine.medical_treatmentImmunologySodium hyaluronateGlycineAntineoplastic AgentsGastroenterologyLesionchemistry.chemical_compoundSettore MED/28 - Malattie OdontostomatologicheLeucineInternal medicinemedicineMucositisHumansImmunology and Allergyhyaluronic acid amino acids oral mucositis oral ulcer spray compound pain wound healingAmino AcidsHyaluronic AcidAdverse effectStomatitisAgedPain MeasurementAged 80 and overPharmacologyStomatitisChemotherapyRadiotherapybusiness.industryLysineMiddle Agedmedicine.diseaseSurgeryClinical trialchemistryHead and Neck NeoplasmsFemaleCollagenmedicine.symptombusinessInternational Journal of Immunopathology and Pharmacology
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Osteonecrosis of the jaws in patients assuming oral bisphosphonates for osteoporosis: A retrospective multi-hospital-based study of 87 Italian cases

2013

Abstract Background Bisphosphonates (BPs) are currently the chief drugs for the prevention/treatment of osteoporosis; one of their adverse effects is the osteonecrosis of the jaw (BRONJ). The primary endpoints of this multi-center cross-sectional study are: i) an observation of the clinical features of BRONJ in 87 osteoporotic, non-cancer patients; and ii) an evaluation of their demographic variables and comorbidities. Methods 87 BRONJ patients in therapy for osteoporosis with BPs from 8 participating clinical Italian centers were consecutively identified and studied. After BRONJ diagnosis and staging, comorbidities and data relating to local and drug-related risk factors for BRONJ were col…

medicine.medical_specialtyTime FactorsMultivariate analysisHeart DiseasesOsteoporosisSettore MED/50 - Scienze Tecniche Mediche ApplicateAdministration OralMandibleOsteonecrosis jawHospital based studyAdrenal Cortex HormonesRisk FactorsSettore MED/28 - Malattie OdontostomatologicheInternal medicineDiabetes MellitusInternal MedicinemedicineHumansIn patientRisk factorOral bisphopshonateAdverse effectOsteoporosis PostmenopausalAgedRetrospective StudiesAged 80 and overAlendronateBone Density Conservation AgentsDiphosphonatesbusiness.industryLiver DiseasesIncidence (epidemiology)Age FactorsMiddle Agedmedicine.diseaseSurgeryCross-Sectional StudiesItalyOral bisphopshonates; Osteonecrosis jaws; OsteoporosisHypertensionMultivariate AnalysisOsteoporosisBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawbusiness
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Obesity and craniofacial variables in subjects with obstructive sleep apnea syndrome: comparisons of cephalometric values

2007

AbstractBackgroundThe aim of this paper was to determine the most common craniofacial changes in patients suffering Obstructive Sleep Apnea Syndrome (OSAS) with regards to the degree of obesity. Accordingly, cephalometric data reported in the literature was searched and analyzed.MethodsAfter a careful analysis of the literature from 1990 to 2006, 5 papers with similar procedural criteria were selected. Inclusion criteria were: recruitment of Caucasian patients with an apnea-hypopnea index (AHI) >10 as grouped in non-obese (Body Mass Index – [BMI] < 30)vs. obese (BMI ≥ 30).ResultsA low position of the hyoid bone was present in both groups. In non-obese patients, an increased value of t…

AdultMalePediatricsmedicine.medical_specialtylcsh:Specialties of internal medicineCephalometryPolysomnographyClinical NeurologyDentistryReviewPolysomnographySensitivity and SpecificitySeverity of Illness IndexBody Mass IndexTonguelcsh:RC581-951Reference ValuesRisk FactorsSeverity of illnessmedicineHumansObesityCraniofacialGeneral DentistryAgedSleep Apnea Obstructivemedicine.diagnostic_testDentistry(all)business.industryIncidenceSleep apneaMiddle AgedCraniometrymedicine.diseaseObesityrespiratory tract diseasesObstructive sleep apneaJawOtorhinolaryngologyCase-Control StudiesPharynxFemaleNeurology (clinical)Palate SoftbusinessBody mass indexHead & Face Medicine
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Oral Squamous Cell Carcinoma on Gingiva, Edentulous Ridge, and Retromolar Pad: A Case Series

2021

(1) Background: Gingival cancer has a significant incidence and is often diagnosed at advanced stages. The aim of this paper is to highlight its clinical aspects on the basis of a case series analysis in order to promote awareness and improve the diagnosis process. (2) Methods: Oral cancers diagnosed and treated at three Italian University Hospitals over ten years were retrospectively investigated. Cancer location on the gingiva, edentulous ridge, and retromolar pad was addressed. Data regarding clinical features, stage at the diagnosis, and time from presenting symptoms to first medical consultation were retrieved. (3) Results: Thirty-three cancers located on the gingiva, edentulous ridge,…

business.industrydiagnosisIncidence (epidemiology)MandibleCancerDentistryClinical appearanceMedical evaluationRK1-715030206 dentistryoral cancermedicine.diseaseAsymptomaticgingiva03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisDentistrymedicineBasal cellclinical appearanceStage (cooking)medicine.symptombusiness
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Spontaneous bisphosphonate-related osteonecrosis of the left hemi-mandible: Similarities with phossy jaw.

2013

Intravenous bisphosphonates (BP) play a key role in the treatment of bone metastases. As a long-term side effects BP, a form of avascular osteonecrosis of the jaw has been reported. Although, invasive oral local procedures are often present in clinical history of patients suffering from bisphosphonates-related osteonecrosis of the jaws (BRONJ), about up to 50% of BRONJ are spontaneous. We report a case of a 68-year-old female with a spontaneous wide bone sequestration of the left mandibular body onset after infusion of zoledronic acid for 18 cycles for osseous metastasis due to metastatic anaplastic thyroidal carcinoma. Surprisingly the clinical aspects of the patient initially reminded us …

medicine.medical_specialtyLung Neoplasmsmedicine.medical_treatmentBone NeoplasmsZoledronic AcidBone sequestrationstomatognathic systemMandibular bodySettore MED/28 - Malattie OdontostomatologichemedicineCarcinomaHumansMandibular DiseasesThyroid Neoplasmsthyroidal carcinomaGeneral DentistryAgedPhossy jawBone Density Conservation AgentsDiphosphonatesbusiness.industryCarcinomaMandibleImidazolesBisphosphonatesGeneral MedicineBisphosphonatemedicine.diseaseBisphosphonatesbisphosphonates‑related osteonecrosis of the jaws thyroidal carcinoma zoledronic acidbisphosphonates-related osteonecrosis of the jawsSurgerylcsh:RK1-715stomatognathic diseasesZoledronic acidlcsh:DentistryBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawbusinessmedicine.drugFollow-Up Studies
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Clinical validation of 13-gene DNA methylation analysis in oral brushing samples for detection of oral carcinoma: an Italian multicenter study

2021

Background The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13-gene DNA methylation analysis in oral brushing samples. Methods Oral brushing specimens were collected in 11 oral medicine centers across Italy. Twenty brushing specimens were collected by each center, 10 from patients with OSCC, and 10 from healthy volunteers. DNA methylation analysis was performed in blindness, and each sample was determined as positive or negative based on a predefined cutoff value. Results DNA amplification failed in 4 of 220 (1.8%) samples. Of the specimens derived from patien…

0301 basic medicinemedicine.medical_specialtyBisulfite sequencingalgorithm; bisulfite sequencing; diagnostic test; oral brushing; oral squamous cell carcinoma; quantitative DNA methylation analysisGastroenterologyoral brushing03 medical and health sciences0302 clinical medicineInternal medicineHealthy volunteersCarcinomamedicineHumansquantitative DNA methylation analysisMouth neoplasmalgorithmbusiness.industryDNA Methylationmedicine.diseaseDna amplificationoral squamous cell carcinomastomatognathic diseases030104 developmental biologyItalyOtorhinolaryngologyMulticenter studyHead and Neck Neoplasmsdiagnostic test030220 oncology & carcinogenesisDNA methylationCarcinoma Squamous Cellbisulfite sequencingMouth NeoplasmsbusinessOral medicine
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Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the S…

2022

Abstract Background Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. Methods 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality In…

OralCross-Sectional StudieLichen PlanusItaly; Oral lichen planus; Pain; Psychological profile; Sleep disturbancesSleep disturbancePainSleep disturbancesAnxietySettore MED/28 - MALATTIE ODONTOSTOMATOLOGICHECross-Sectional StudiesOral lichen planuItalyPsychological profileItaly; Oral lichen planus; Pain; Psychological profile; Sleep disturbances; Anxiety; Cross-Sectional Studies; Humans; Pain; Pathology Oral; Lichen Planus OralOral lichen planusPathologyPathology OralHumansGeneral DentistryHumanLichen Planus Oral
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Staging of osteonecrosis of the jaw requires computed tomography for accurate definition of the extent of bony disease

2014

AbstractManagement of osteonecrosis of the jaw associated with antiresorptive agents is challenging, and outcomes are unpredictable. The severity of disease is the main guide to management, and can help to predict prognosis. Most available staging systems for osteonecrosis, including the widely-used American Association of Oral and Maxillofacial Surgeons (AAOMS) system, classify severity on the basis of clinical and radiographic findings. However, clinical inspection and radiography are limited in their ability to identify the extent of necrotic bone disease compared with computed tomography (CT). We have organised a large multicentre retrospective study (known as MISSION) to investigate th…

AdultMaleCutaneous FistulaSettore MED/50 - Scienze Tecniche Mediche ApplicateDental Fistulastaging system; bisphosphonate; computed tomography; aaoms; osteonecrosis of the jaw; antiresorptive agentsAAOMSAntiresorptive agentSettore MED/29 - Chirurgia MaxillofaccialeAAOMS Antiresorptive agents Bisphosphonate Computed tomography Osteonecrosis of the jaw Staging systemBronj; AAOMS; Antiresorptive agents; Bisphosphonate; Computed tomography; Osteonecrosis of the jaw; Staging systemSettore MED/28 - Malattie OdontostomatologicheMandibular FracturesBronjOsteonecrosis of the jaw; Bisphosphonate; Staging system; AAOMS; Computed tomography; Antiresorptive agentsAlveolar ProcessHumansBisphosphonateMandibular DiseasesComputed tomographyAgedRetrospective StudiesAged 80 and overSuppurationBone Density Conservation AgentsOsteonecrosis of the jawPatient AcuityAntiresorptive agentsCone-Beam Computed TomographyMiddle AgedStaging systemMaxillary DiseasesPhenotypeOtorhinolaryngologyTooth ExtractionBisphosphonate-Associated Osteonecrosis of the JawDrug Therapy CombinationFemaleSurgeryOsteonecrosis of the jaw; Bisphosphonate; Staging system; AAOMS; Computed tomography; Antiresorptive agentsAAOMS; Antiresorptive agents; Bisphosphonate; Computed tomography; Osteonecrosis of the jaw; Staging systemOral SurgeryTomography X-Ray ComputedTomography Spiral ComputedOsteosclerosis
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Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Socie…

2019

On 20 October 2018 a Closed Round Table brought together a wide range of stakeholders from several medical disciplines, including academic experts, dentists, oncologists, maxillo-facial surgeons, oral surgeons, radiologists, under the technical and scientific coordination of Giuseppina Campisi (for SIPMO) and Giacomo Oteri (for Italian Society of Oral Surgery- SIdCO)

SIPMOBRONJ (bisphosphonate-related osteonecrosis of the jaw)Risk of inappropriatenessSIdCOPhysiologyPhysiology (medical)Italian consensus mrojMRONJ Italian ConsensusMRONJONJ (osteonecrosis of the jaws)BRONJ (bisphosphonate-related osteonecrosis of the jaw)Risk of inappropriatenessMRONJ Italian ConsensusSIPMOSIdCOMRONJONJ (osteonecrosis of the jaws)
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PROLIFERATIVE VERRUCOUS VS CLASSIC LEUKOPLAKIA: NO DIFFERENT RISK OF HPV – INFECTION.

2004

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