0000000000613846
AUTHOR
W. Braunbeck
Respiratory GAS Exchange and pO2- Distribution in Splenic Tissue
Little attention has been paid to physiological aspects of O2 supply to splenic tissue. Studies are performed to examine the factors determining the supply conditions for the rabbit’s spleen, which has little reservoir function and, therefore, it is very similar to the human spleen. Previous studies on respiratory gas exchange, applying the arterial and spleno-venous blood gas values, have shown a mean arterio-venous O2-difference of 0.5 Vol.% (2). Taking into account a mean splenic blood flow of 110 ml/100g/min (12), the O2 consumption of splenic tissue amounts to 0.6 ml/100g/min.
A Contribution Concerning the Unsettled Problem of Intrasplenic Microcirculation
From morphological studies it is well known that the vascular bed of the spleen consists of at least two different compartments. Figure one schematically shows how the splenic microcirculation can be subdivided. One compartment corresponds to the white pulp (pathways number 1 and 2), the other compartment to the red pulp, for which the existance of either an open or a closed type of terminal vascular bed is discussed. Futhermore there are references that the microcirculation in the red pulp is not homogeneous but composed of both types, as illustrated by the pathways marked by number 3 and 4.
Experimentelle und theoretische Untersuchungen der intralienalen Mikrozirkulation beim Kaninchen
1. Bei 57 spontanatmenden Kaninchen wird in Ketaminnarkose mit Hilfe der85Kr(β)-Auswaschtechnik nach Stosinjektion des gelosten Indikators in die Aorta die regionale Milzdurchblutung gemessen. 2. Bei der normalen, unbeeinflusten Milzin situ besteht im Bereich von 65–125 mm Hg eine lineare Abhangigkeit der regionalen Milzdurchblutung vom arteriellen Mitteldruck (2p < 0,001). Bei einem mittleren Druck von 97 mm Hg betragt die mittlere Milzdurchblutung 1,23 ml/g/min. 3. Nach totaler Obstruktion der offenen Strombahn durch Applikation rigider Spharocyten ist die Durchblutung im gleichen Blutdruckbereich unabhangig vom arteriellen Mitteldruck. Nach Ausschaltung der offenen Strombahn betragt die …