0000000000618704

AUTHOR

Mohamed A. Farag

showing 3 related works from this author

Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: A mechanistic study

2019

Abstract Background Gastric ulcer is one of the main prevalent gastrointestinal multi-etiological disorders with many associated complications and adverse effects. Our aim was to develop safer antiulcer therapies based on methanol or ethyl acetate extracts of tubers and aerial parts from Cyperus alternifolius. Methods Gastric ulceration was experimentally generated by administration of single oral doses of indomethacin (30 mg/kg) to fasted rats. The animals received methanol or ethyl acetate extracts of C. alternifolius tuber and methanol or ethyl acetate extracts of aerial parts at two dose levels (50 or 100 mg/kg). Ranitidine (50 mg/kg) was used as standard anti-ulcer drug. After 4 h, the…

Malemedicine.drug_classAntiulcer drugMetaboliteIndomethacinPhytochemicalsAnti-Inflammatory AgentsEthyl acetatePharmaceutical ScienceAcetatesAnti-inflammatoryRanitidine03 medical and health scienceschemistry.chemical_compound0302 clinical medicineTandem Mass SpectrometryDrug DiscoverymedicineMetabolomeAnimalsMetabolomicsStomach UlcerCyperusRats WistarAcetic Acid030304 developmental biologyPharmacology0303 health sciencesTraditional medicinebiologyPlant ExtractsChemistryMethanolPlant Components AerialAnti-Ulcer Agentsbiology.organism_classificationRatsCyperus alternifoliusPlant TubersComplementary and alternative medicinePhytochemicalGastric Mucosa030220 oncology & carcinogenesisMetabolomeMolecular MedicineChromatography Liquidmedicine.drugPhytomedicine
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Litchi (Litchi chinensis Sonn.): a comprehensive review of phytochemistry, medicinal properties, and product development

2021

Since ancient times, litchi has been well recognized as a functional food for the management of various ailments. Many bioactives, including flavanoids, anthocyanins, phenolics, sesquiterpenes, triterpenes, and lignans, have been identified from litchi with a myriad of biological properties both in vitro and in vivo. In spite of the extensive research progress, systemic reviews regarding the bioactives of litchi are rather scarce. Therefore, it is crucial to comprehensively analyze the pharmacological activities and the structure-activity relationships of the abundant bioactives of litchi. Besides, more and more studies have focused on litchi preservation and development of its by-products,…

PhytochemistryFunctional foodbusiness.industryBiological propertyRelationship analysisPhytochemical compositionGeneral MedicineBiologyHealth benefitsbusinessFood ScienceBiotechnologyFood & Function
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Cardenolides: Insights from chemical structure and pharmacological utility

2019

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na

0301 basic medicinePharmacologyClass (computer programming)Isolation (health care)Chemical structureAntineoplastic AgentsCardiovascular AgentsComputational biologyIndustrial biotechnologyBiologyCardenolides03 medical and health sciences030104 developmental biology0302 clinical medicine030220 oncology & carcinogenesisAnimalsHumansDiureticsPharmacological Research
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