6533b859fe1ef96bd12b6e7e

RESEARCH PRODUCT

Cardenolides: Insights from chemical structure and pharmacological utility

Muaaz AlajlaniDiaa T. A. YoussefMohamed-elamir F. HegazySyed Ghulam MusharrafMohamed GamalThomas A. EfferthJianbo XiaoMohamed A. FaragEman A. TaherShaden A. M. KhalifaAamer SaeedHesham R. El-seedi

subject

0301 basic medicinePharmacologyClass (computer programming)Isolation (health care)Chemical structureAntineoplastic AgentsCardiovascular AgentsComputational biologyIndustrial biotechnologyBiologyCardenolides03 medical and health sciences030104 developmental biology0302 clinical medicine030220 oncology & carcinogenesisAnimalsHumansDiuretics

description

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na

yearjournalcountryeditionlanguage
2019-03-01Pharmacological Research
https://doi.org/10.1016/j.phrs.2018.12.015