0000000000632625

AUTHOR

ÁLvaro Pascual

showing 3 related works from this author

Characterization of the Carbapenem-Hydrolyzing Oxacillinase Oxa-58 in an Acinetobacter Genospecies 3 Clinical Isolate

2008

ABSTRACT Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first time in this genomic species, a plasmid-encoded bla OXA-58 gene that was 100% homologous to the same gene in Acinetobacter baumannii .

ImipenemCarbapenemMolecular Sequence DataMicrobial Sensitivity TestsBiologybeta-LactamasesMicrobiologyPlasmidBacterial ProteinsMechanisms of Resistancepolycyclic compoundsmedicineHumansPharmacology (medical)Antibacterial agentPharmacologyAcinetobacterBase SequenceSequence Analysis DNAbiochemical phenomena metabolism and nutritionAcinetobacterbacterial infections and mycosesbiology.organism_classificationAnti-Bacterial AgentsAcinetobacter baumanniiImipenemInfectious DiseasesCarbapenemsNeisseriaceaeBacteriaAcinetobacter InfectionsPlasmidsmedicine.drugAntimicrobial Agents and Chemotherapy
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Molecular topology: A new strategy for antimicrobial resistance control

2017

The control of antimicrobial resistance (AMR) seems to have come to an impasse. The use and abuse of antibacterial drugs has had major consequences on the genetic mutability of both pathogenic and nonpathogenic microorganisms, leading to the development of new highly resistant strains. Because of the complexity of this situation, an in silico strategy based on QSAR molecular topology was devised to identify synthetic molecules as antimicrobial agents not susceptible to one or several mechanisms of resistance such as: biofilms formation (BF), ionophore (IA) activity, epimerase (EI) activity or SOS system (RecA inhibition). After selecting a group of 19 compounds, five of them showed signific…

0301 basic medicineQuantitative structure–activity relationshipStaphylococcusIn silico030106 microbiologyMicrobial Sensitivity Testsmedicine.disease_causeMicrobiologyStructure-Activity Relationship03 medical and health sciencesAntibiotic resistanceDrug Resistance BacterialDrug DiscoveryEnterococcus faecalisEscherichia colimedicineEscherichia coliPharmacologyVirtual screeningDose-Response Relationship DrugMolecular StructureChemistryOrganic ChemistryBiofilmGeneral MedicineAntimicrobialAnti-Bacterial Agents030104 developmental biologyBiofilmsRegression AnalysisStaphylococcusEuropean Journal of Medicinal Chemistry
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Enhanced Antibacterial Activity of Repurposed Mitomycin C and Imipenem in Combination with the Lytic Phage vB_KpnM-VAC13 against Clinical Isolates of…

2021

Study Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA) on behalf of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).

0301 basic medicineImipenemKlebsiella pneumoniaemedicine.drug_classMitomycin030106 microbiologyAntibioticsResistanceDrug repurposingMicrobial Sensitivity TestsBacteriophage therapybeta-LactamasesMicrobiologyPersistence03 medical and health sciencesMechanisms of Resistancemedicinepolycyclic compoundsHumansPharmacology (medical)BacteriophagesPathogenhealth care economics and organizationsPharmacologybiologyMitomycin CBroth microdilutionbiochemical phenomena metabolism and nutritionbiology.organism_classificationAntimicrobialhumanitiesAnti-Bacterial AgentsKlebsiella InfectionsSynergyImipenemKlebsiella pneumoniae030104 developmental biologyInfectious DiseasesLytic cyclemedicine.drugAntimicrobial agents and chemotherapy
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