0000000000646698

AUTHOR

Claudia I. Caldiz

showing 2 related works from this author

Ex Vivo Treatment with a Polyphenol-Enriched Cocoa Extract Ameliorates Myocardial Infarct and Postischemic Mitochondrial Injury in Normotensive and H…

2016

Our objective was to determine the effects of a polyphenol-enriched cocoa extract (PCE) on myocardial postischemic alterations in normotensive (Wistar rats, W) and spontaneously hypertensive rats (SHR). Isolated hearts were submitted to 110 min of perfusion or 20 min stabilization, 30 min global ischemia, and 60 min reperfusion (R). Other hearts were treated with PCE at the onset of R. Infarct size, the reduced glutathione (GSH), and the expression of phospho-Akt, P-GSK-3β, and P-eNOS were assessed. In isolated mitochondria, the Ca2+-mediated response of mitochondrial permeability transition pore (mPTP), membrane potential (δψm), and superoxide production were determined. PCE decreased infa…

Male0301 basic medicineMyocardial InfarctionWistarBlood Pressure030204 cardiovascular system & hematologyPharmacologyMitochondrial Membrane Transport ProteinsInfarct sizeSHRGlycogen Synthase Kinase 3chemistry.chemical_compound0302 clinical medicineMITOCHONDRIAIschemiaSuperoxidesEnosRats Inbred SHRbiologySuperoxideMPTPINFARCT SIZEHeart//purl.org/becyt/ford/3.1 [https]GlutathioneMitochondriaMedicina BásicaHypertension//purl.org/becyt/ford/3 [https]General Agricultural and Biological SciencesPerfusionCocaCardiotonic AgentsCIENCIAS MÉDICAS Y DE LA SALUDInmunologíaIschemiaIn Vitro Techniques03 medical and health sciencesPOLYPHENOLSWISTARmedicineAnimalsHumansRats WistarSHR; Wistar; infarct size; mitochondria; polyphenolsMitochondrial Permeability Transition PorePlant ExtractsMyocardiumCocoa ExtractPolyphenolsGeneral ChemistryGlutathionemedicine.diseasebiology.organism_classificationRats030104 developmental biologychemistryMitochondrial permeability transition poreCiencias MédicasJournal of Agricultural and Food Chemistry
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Effect of an Ilex paraguariensis (yerba mate) extract on infarct size in isolated rat hearts: the mechanisms involved

2016

Tea made from Ilex paraguariensis (IP) dried and minced leaves is a beverage widely consumed by large populations in South America as a source of caffeine (stimulant action) and for its medicinal properties. However, there is little information about the action of IP on the myocardium in the ischemia-reperfusion condition. Therefore, the objective of this study was to examine the effects of an aqueous extract of IP on infarct size in a model of regional ischemia. Isolated rat hearts were perfused by the Langendorff technique and subjected to 40 min of coronary artery occlusion followed by 60 min of reperfusion (ischemic control hearts). Other hearts received IP 30 μg mL-1 during the first 1…

0301 basic medicineMaleCIENCIAS MÉDICAS Y DE LA SALUDThiobarbituric acidIschemiaInmunologíaMyocardial InfarctionPharmacologyIn Vitro TechniquesIlex Paraguariensis03 medical and health scienceschemistry.chemical_compoundfoodIlex paraguariensisYerba-mateTBARSMedicineAnimalsHumansRats WistarIschemia-Reperfusionbiologybusiness.industryPlant ExtractsMyocardiumHeartGeneral MedicineGlutathione//purl.org/becyt/ford/3.1 [https]medicine.diseaseGlutathionefood.foodRatsNitric oxide synthaseMedicina Básica030104 developmental biologyMitochondrial permeability transition poreBiochemistrychemistrybiology.protein//purl.org/becyt/ford/3 [https]Nitric Oxide SynthasebusinessCaffeineFood Science
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