0000000000653910

AUTHOR

F. M. Mottaghy

showing 3 related works from this author

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

2008

In the present study we aimed to explore by means of repetitive transcranial magnetic stimulation (rTMS) the reciprocal influences between prefrontal cortex (PFC) and premotor cortex (PMC). Subjects were asked to observe on a computer monitor different pictures representing manipulations of different kind of tools. They had to produce a movement (go condition) or to keep the resting position (no-go condition) at the appearance of different cue signals represented by different colors shown alternatively on the hands manipulating the tools or on the picture background. Motor evoked potentials (MEPs) were collected at the offset of the visual stimuli before and after a 10 minute, 1 Hz rTMS tra…

AdultMaleVisual perceptionSocial Psychologymedia_common.quotation_subjectmedicine.medical_treatmentDecision MakingPrefrontal Cortextranscranial magnetic stimulation prefrontal cortex mirror neuronsDevelopmentMotor ActivityNeuropsychological Testsbehavioral disciplines and activitiesFunctional LateralityPremotor cortexBehavioral NeurosciencePerceptionmedicineHumansPrefrontal cortexMirror neuronmedia_commonAnalysis of VarianceBrain MappingElectromyographyMotor CortexBody movementEvoked Potentials MotorMagnetic Resonance ImagingTranscranial Magnetic StimulationElectric StimulationTranscranial magnetic stimulationmedicine.anatomical_structurenervous systemPattern Recognition VisualFemalePrimary motor cortexPsychologyNeuroscienceColor PerceptionPhotic Stimulation
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Synthesis and evaluation of 18F-fluoroethylated benzothiazole derivatives for in vivo imaging of amyloid plaques in Alzheimer's disease

2010

Amyloid aggregates play a major role in the development of Alzheimer's disease. Targeting these aggregates by PET probes enables non-invasively the detection and quantification of amyloid deposit distribution in human brains. Based on benzothiazole core structure a series of amyloid imaging agents were developed. Currently [(11)C]2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (Pittsburgh Compound-B (PIB) is the most specific and widely used amyloid imaging ligand. But due to the short half life of (11)C, longer lived (18)F-labeled derivatives offer logistic advantages and higher contrast images. In this work, three different [(18)F]fluoroethoxy-substituted benzothiazole derivatives ([(18…

AmyloidFluorine RadioisotopesAmyloidStereochemistryPlaque AmyloidAmyloid plaquesMice SCIDScid miceMicechemistry.chemical_compoundAlzheimer DiseasemedicineAnimalsBenzothiazolesRadiationChemistryBrainHuman brainAlzheimer's diseasemedicine.diseaseLigand (biochemistry)Fluorine-18PETmedicine.anatomical_structureBenzothiazolePositron-Emission TomographyLipophilicityRadiopharmaceuticalsAlzheimer's diseasePreclinical imagingApplied Radiation and Isotopes
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Repetitive TMS temporarily alters brain diffusion

2004

The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1 that disappeared after 5 minutes. These findings provide a physiologic correlate to the reported behavioral consequences of off-line 1-Hz rTMS and reveal the transitory nature of the effects.

Motor thresholdAdultMaleTime Factorsmedicine.medical_treatmentMotor Cortexdiffusion-weighted imaging repetitive transcranial magnetic stimulationMagnetic Resonance ImagingTranscranial magnetic stimulationDiffusionMagneticsmedicineHumansNeurology (clinical)Primary motor cortexDiffusion (business)PsychologyNeuroscience
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