0000000000659041

AUTHOR

R. Milojcic

showing 2 related works from this author

Improved Regeneration of Autologous Nerve Transplants by Means of VEGF-Gene Therapy

2009

The impact of the Vascular Endothelial Growth Factor (VEGF) on the angiogenic cascade is proven. Recently its neuroprotective effect after peripheral nerve injuries on α-motoneurons in the spinal cord was shown. Experiments on α-motoneurons demonstrated a decreased sensitivity to ischemia under VEGF-therapy. Aim of the study was to elucidate the effect of a localized VEGF-gene-therapy using an adenoviral vector construct in the model of a peripheral nerve defect in the rat treated with an autologous nerve transplant.

Pathologymedicine.medical_specialtybiologybusiness.industryVEGF receptorsIschemiaSpinal cordmedicine.diseaseNeuroprotectionViral vectorVascular endothelial growth factorchemistry.chemical_compoundmedicine.anatomical_structurechemistryPeripheral nerveDecreased Sensitivitybiology.proteinMedicinebusiness
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Improved Regeneration of Autologous Nerve Transplants by Means of VEGF-Gene Therapy

2009

The impact of the Vascular Endothelial Growth Factor (VEGF) on the angiogenic cascade is proven. Recently its neuroprotective effect after peripheral nerve injuries on α-motoneurons in the spinal cord was shown. Experiments on α-motoneurons demonstrated a decreased sensitivity to ischemia under VEGF-therapy. Aim of the study was to elucidate the effect of a localized VEGF-gene-therapy using an adenoviral vector construct in the model of a peripheral nerve defect in the rat treated with an autologous nerve transplant.

medicine.medical_specialtyPathologybiologybusiness.industryGenetic enhancementRegeneration (biology)VEGF receptorsIschemiamedicine.diseaseSpinal cordNeuroprotectionSurgeryViral vectorVascular endothelial growth factorchemistry.chemical_compoundmedicine.anatomical_structurechemistrymedicinebiology.proteinSurgerybusinessJournal of Plastic, Reconstructive & Aesthetic Surgery
researchProduct