6533b860fe1ef96bd12c2dc4
RESEARCH PRODUCT
Improved Regeneration of Autologous Nerve Transplants by Means of VEGF-Gene Therapy
R. MilojcicMoritz A. KonerdingBernd GansbacherHans-guenther MachensR. E. GiuntaT. HolzbachMartina AntonT. Brillsubject
medicine.medical_specialtyPathologybiologybusiness.industryGenetic enhancementRegeneration (biology)VEGF receptorsIschemiamedicine.diseaseSpinal cordNeuroprotectionSurgeryViral vectorVascular endothelial growth factorchemistry.chemical_compoundmedicine.anatomical_structurechemistrymedicinebiology.proteinSurgerybusinessdescription
The impact of the Vascular Endothelial Growth Factor (VEGF) on the angiogenic cascade is proven. Recently its neuroprotective effect after peripheral nerve injuries on α-motoneurons in the spinal cord was shown. Experiments on α-motoneurons demonstrated a decreased sensitivity to ischemia under VEGF-therapy. Aim of the study was to elucidate the effect of a localized VEGF-gene-therapy using an adenoviral vector construct in the model of a peripheral nerve defect in the rat treated with an autologous nerve transplant.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-06-01 | Journal of Plastic, Reconstructive & Aesthetic Surgery |