0000000000671801
AUTHOR
J. Bailey
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg was investigated through 96 weeks in EMERALD (NCT02269917). Virologically-suppressed, HIV-1-positive treatment-experienced adults (previous non-darunavir virologic failure [VF] allowed) were randomized (2:1) to D/C/F/TAF or boosted protease inhibitor (PI) plus emtricitabine/tenofovir-disoproxil-fumarate (F/TDF) over 48 weeks. At week 52 participants in the boosted PI arm were offered switch to D/C/F/TAF (late-switch, 44 weeks D/C/F/TAF exposure). All participants were followed on D/C/F/TAF until week 96. Efficacy endpoints were percentage cumulative protocol-defined virologic rebound (PDVR; confirmed vira…
The anomalous magnetic moment of positive and negative muons
Abstract The anomalous g -factor a ≡ ( g −2)/2 has been measured for muons of both charges in the Muon Storage Ring at CERN. The two results, a μ + = 1165910(12) × 10 −9 and a μ − = 1165936(12) × 10 −9 , are in good agreement with each other, and combine to give a mean a μ = 1165922(9) × 10 −9 , which is very close to the most recent theoretical prediction 1165921(10) × 10 −9 . For the experimental results, the total statistical and systematic error is given. The measurements thus confirm the remarkable QED calculation plus hadronic contribution, and serve as a precise verification of the CPT theorem for muons.
The πd scattering length from Kα X-rays
Abstract X-rays from the K α transition (2P → 1S) of the π − d mesic atom have been observed. Their energy, 2592.8 −2.0 +1.6 , has been measured by the critical absorber technique, using the M V absorption edge in bismuth. The strong interaction shift in the 1S state is −4.8 eV, corresponding to a scattering length a ( π d) = −(0.052 −0.017 +0.022 ) m π −1 , in agreement with recent calculations. The intensity ratio K α /K total = 0.548 ± 0.015.
Final report on the CERN muon storage ring including the anomalous magnetic moment and the electric dipole moment of the muon, and a direct test of relativistic time dilation
Abstract A comprehensive description of the muon storage ring and its operation is given, and the final results of the experiment are presented and discussed. The anomalous magnetic moments of positive and negative muons are found to be aμ+ = 1165911(11) × 10−9 and aμ− = 1165937(12) × 10−9 giving an average value for muons of aμ = 1165924(8.5) × 10−9. The electric dipole moments were also measured with the results Dμ+= (8.6 ± 4.5) × 10−9e · cm and Dμ− = (0.8 ± 4.3) × 10−19e · cm. Under the assumption of the CPT theorem these yield a weighted average of Dμ = (3.7 ± 3.4) × 10−19e · cm. Finally the time transformation of special relativity is shown to be valid to (0.8 ± 0.7) × 10−3 at γ ≅ 29.3…
Measurements of relativistic time dilatation for positive and negative muons in a circular orbit
The lifetimes of both positive and negative relativistic (γ = 29.33) muons have been measured in the CERN Muon Storage Ring with the results τ+ = 64.419 (58) µs, τ− = 64.368 (29) µs The value for positive muons is in accordance with special relativity and the measured lifetime at rest: the Einstein time dilation factor agrees with experiment with a fractional error of 2×10−3 at 95% confidence. Assuming special relativity, the mean proper lifetime for μ− is found to be τ0− = 2.1948(10) µs the most accurate value reported to date. The agreement of this value with previously measured values of τ0+ confirms CPT invariance for the weak interaction in muon decay.