0000000000679064

AUTHOR

Maria Eugenia Poo

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Defining the genomic signature of totipotency and pluripotency during early human development.

2013

The genetic mechanisms governing human pre-implantation embryo development and the in vitro counterparts, human embryonic stem cells (hESCs), still remain incomplete. Previous global genome studies demonstrated that totipotent blastomeres from day-3 human embryos and pluripotent inner cell masses (ICMs) from blastocysts, display unique and differing transcriptomes. Nevertheless, comparative gene expression analysis has revealed that no significant differences exist between hESCs derived from blastomeres versus those obtained from ICMs, suggesting that pluripotent hESCs involve a new developmental progression. To understand early human stages evolution, we developed an undifferentiation netw…

EmbryologyBlastomeresMicroarraysCellular differentiationGene ExpressionCell Fate DeterminationMolecular Cell BiologyGene Regulatory NetworksInduced pluripotent stem cellreproductive and urinary physiologyGeneticsMultidisciplinarySystems BiologyStem CellsQTotipotentRGenomic signatureCell DifferentiationGenomicsCell biologyFunctional GenomicsBlastocyst Inner Cell MassBlastocyst Inner Cell Massembryonic structuresMedicineResearch ArticlePluripotent Stem CellsSystems biologyCell PotencyScienceEmbryonic DevelopmentBiologyMolecular GeneticsGeneticsHumansGene NetworksBiologyEmbryonic Stem CellsGenome HumanGene Expression ProfilingBio-OntologiesComputational BiologyMolecular Sequence AnnotationComparative GenomicsMolecular DevelopmentEmbryonic stem cellSignalingSignaling NetworksGene expression profilingGenome Expression AnalysisTotipotent Stem CellsDevelopmental BiologyPLoS ONE
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