0000000000684463
AUTHOR
P. Knoblauch
showing 2 related works from this author
Iontophoretic in Vitro Release of Antimycotics from Hydrogels
1993
A new in vitro model for iontophoretic release from hydrogels was developed. It represents a modification of the rotary disk cell developed by Moll/Bender and can be used in a normal dissolution tester. The iontophoretic release from antimycotic hydrogels through an artificial membrane was investigated and different types of antimycotics were tested. The influence of current density, drug concentration and vehicle was determined.
In vitro pulsatile and continuous transdermal delivery of buserelin by iontophoresis
1993
Abstract Transdermal delivery of buserelin, a nonapeptide, from hydroxyethylcellulose hydrogel through isolated human stratum comeum was studied. In vitro studies were carried out in a drug release apparatus (DAB 10/USP XII) using self designed rotary disk cells equipped with platinum electrodes. Different forms of current were examined. A pulsatile application of continuous current resulted in a step-like permeation profile. Different on/off ratios (5 min/55 min; 10 min/50 min; 15 min/45 min)) were studied. When continuous non-interrupted current with different current densities (0.1–0.3 mA·cm −2 ) was applied, linear dependence of the final cumulative amount of buserelin on current durati…