6533b82cfe1ef96bd128e9a5

RESEARCH PRODUCT

Iontophoretic in Vitro Release of Antimycotics from Hydrogels

P. KnoblauchF. Moll

subject

PharmacologyActive ingredientIontophoresisChemistryOrganic ChemistrySynthetic membranePharmaceutical SciencePharmacologyDosage formIn vitroIn vitro modelDrug DiscoverySelf-healing hydrogelsBiophysicsLiberation

description

A new in vitro model for iontophoretic release from hydrogels was developed. It represents a modification of the rotary disk cell developed by Moll/Bender and can be used in a normal dissolution tester. The iontophoretic release from antimycotic hydrogels through an artificial membrane was investigated and different types of antimycotics were tested. The influence of current density, drug concentration and vehicle was determined.

https://doi.org/10.3109/03639049309063008