0000000000704363
AUTHOR
Laurel Kincl
0329 Occupational exposure to metals and welding fumes, and risk of glioma in the interocc study
Background Brain tumouraetiology is poorly understood. Based on their ability to pass through the blood-brain barrier, it has been hypothesised that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are inconsistent. Methods We investigated the relationship between glioma risk and occupational exposure to five metals - lead, cadmium, nickel, chromium and iron- as well as to welding fumes, using data from the seven-country INTEROCC study. A total of 1800 incident glioma cases and 5160 controls aged 30–69 years were included in the analysis. Lifetime occupational exposure to the agents was assessed using the INTEROCC JEM, a mo…
Occupational solvent exposure and risk of glioma in the INTEROCC study
BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-r…