Occupational solvent exposure and risk of glioma in the INTEROCC study

6533b86efe1ef96bd12cc057

RESEARCH PRODUCT

Occupational solvent exposure and risk of glioma in the INTEROCC study

Klaus Schlaefer Martie Van Tongeren Daniel Krewski Jack Siemiatycki Maria Blettner Geza Benke Jordi Figuerola Sarah Fleming Martine Hours Elisabeth Cardis Michelle C. Turner Lesley Richardson Laurel Kincl Marie-élise Parent Siegal Sadetzki Siegal Sadetzki Brigitte Schlehofer David Mclean

subject

Male Oncology MESH: United Kingdom Cancer Research Epidemiology [SDV]Life Sciences [q-bio]MESH: Neoplasm Grading MESH: Solvents MESH: Occupational Exposure MESH: Glioma Tumor grade chemistry.chemical_compound 0302 clinical medicine Risk Factors MESH: New Zealand MESH: Risk Factors Germany Odds Ratio Israel Young adult MESH: Aged Occupation MESH: Middle Aged Brain Neoplasms Age Factors MESH: Israel Glioma Middle Aged 030210 environmental & occupational health MESH: Case-Control Studies 3. Good health Oncology MESH: Young Adult 030220 oncology & carcinogenesis Solvent MESH: Brain Neoplasms Female France Adult Canada medicine.medical_specialty Adolescent Case–control study Job-exposure matrix MESH: Australia Young Adult 03 medical and health sciences Sex Factors MESH: Sex Factors MESH: Canada Occupational Exposure Internal medicine Glioma medicine Journal Article Humans MESH: Germany Aged MESH: Adolescent MESH: Age Factors MESH: Humans business.industry Australia Case-control study MESH: Adult Odds ratio medicine.disease United Kingdom Confidence interval MESH: Male MESH: Odds Ratio MESH: France chemistry Case-Control Studies Solvents Neoplasm Grading Solvent exposure business MESH: Female New Zealand

description

BACKGROUND: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.METHODS: Data from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.RESULTS: Analysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.CONCLUSIONS: The results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.British Journal of Cancer advance online publication 14 September 2017; doi:10.1038/bjc.2017.285 www.bjcancer.com.

year	journal	country	edition	language
2017-10-10

10.1038/bjc.2017.285 https://hal-riip.archives-ouvertes.fr/pasteur-01688929