0000000000713685
AUTHOR
Jorge Del Romero
Efectividad del tratamiento antirretroviral combinado de gran actividad en eventos recurrentes de sida en una cohorte de seroconvertores al virus de la inmunodeficiencia humana
Resumen Introduccion La efectividad del tratamiento antirretroviral de gran actividad (TARGA) en la reduccion del tiempo al primer evento definitorio de sida ha sido demostrada por diversos estudios observacionales, pero el efecto en eventos recurrentes de sida no es tan evidente. Material y metodos Se dispone de 1.938 sujetos seroconvertores al VIH de la cohorte GEMES. Se ha utilizado una extension del modelo de Cox para analizar el tiempo desde la seroconversion a cada evento sida, que tiene en cuenta el tiempo entre sucesivos eventos y que permite que el riesgo de referencia cambie con el numero de paciente con sida previos. El calendario se dividio en tres periodos coincidiendo con la d…
Relationship between oral Kaposi ?s sarcoma and HAART : Contribution of two case reports
Two HIV infected patients not receiving Highly Active Antiretroviral Treatment (HAART) presented with epidemic Kaposi?s sarcoma of the oral cavity. One patient initially refused HAART, but when the lesion became large enough to be noticeable he agreed to HAART associated with excision of the intraoral lesion by CO2 laser. The other patient developed KS and progressed to AIDS at two years after ceasing HAART due to adverse effects; he was referred to hospital for renewed administration of HAART. In both cases, the lesions observed in the oral cavity were the first clinical manifestation of AIDS. These reports underline the close relationship between the use of HAART and the control of KS les…
Oral cancer, HPV infection and evidence of sexual transmission
The incidence of oropharyngeal cancer and oral cancer is growing worldwide, both in young non-smokers and in young non-drinkers (smoking and drinking are considered the main risk factors). Epidemiologic studies suggest a strong association between the infection by human papillomavirus (HPV), especially types 16 and 18 (high oncological risk) which have already demonstrated their etiological role in anal tumours as well as in cervix cancer. There is clear epidemiologic evidence that both types of tumours relate to changes in sexual behaviour and that both are linked to sexual transmission of HPV. The number of oral and oropharyngeal cancer cases is rising nowadays, especially among young ind…